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Anilinoquinoline based inhibitors of trypanosomatid proliferation.
Ferrins L, Sharma A, Thomas SM, Mehta N, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Gillingwater K, Pollastri MP. Ferrins L, et al. Among authors: gillingwater k. PLoS Negl Trop Dis. 2018 Nov 26;12(11):e0006834. doi: 10.1371/journal.pntd.0006834. eCollection 2018 Nov. PLoS Negl Trop Dis. 2018. PMID: 30475800 Free PMC article.
Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT).
Akama T, Zhang YK, Freund YR, Berry P, Lee J, Easom EE, Jacobs RT, Plattner JJ, Witty MJ, Peter R, Rowan TG, Gillingwater K, Brun R, Nare B, Mercer L, Xu M, Wang J, Liang H. Akama T, et al. Among authors: gillingwater k. Bioorg Med Chem Lett. 2018 Jan 1;28(1):6-10. doi: 10.1016/j.bmcl.2017.11.028. Epub 2017 Nov 20. Bioorg Med Chem Lett. 2018. PMID: 29169674 Free PMC article.
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.
Begolo D, Vincent IM, Giordani F, Pöhner I, Witty MJ, Rowan TG, Bengaly Z, Gillingwater K, Freund Y, Wade RC, Barrett MP, Clayton C. Begolo D, et al. Among authors: gillingwater k. PLoS Pathog. 2018 Sep 25;14(9):e1007315. doi: 10.1371/journal.ppat.1007315. eCollection 2018 Sep. PLoS Pathog. 2018. PMID: 30252911 Free PMC article.
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