Kill IR - Search Results

1

Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform.

Bikkul MU, Faragher RGA, Worthington G, Meinke P, Kerr ARW, Sammy A, Riyahi K, Horton D, Schirmer EC, Hubank M, Kill IR, Anderson RM, Slijepcevic P, Makarov E, Bridger JM. Bikkul MU, et al. Among authors: kill ir. Genes Chromosomes Cancer. 2019 Jun;58(6):341-356. doi: 10.1002/gcc.22711. Epub 2019 Jan 7. Genes Chromosomes Cancer. 2019. PMID: 30474255 Free PMC article.

2

Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis.

Bridger JM, Kill IR. Bridger JM, et al. Among authors: kill ir. Exp Gerontol. 2004 May;39(5):717-24. doi: 10.1016/j.exger.2004.02.002. Exp Gerontol. 2004. PMID: 15130666

3

The nuclear lamina. Both a structural framework and a platform for genome organization.

Bridger JM, Foeger N, Kill IR, Herrmann H. Bridger JM, et al. Among authors: kill ir. FEBS J. 2007 Mar;274(6):1354-61. doi: 10.1111/j.1742-4658.2007.05694.x. FEBS J. 2007. PMID: 17489093 Free article. Review.

4

Towards a Drosophila model of Hutchinson-Gilford progeria syndrome.

Beard GS, Bridger JM, Kill IR, Tree DR. Beard GS, et al. Among authors: kill ir. Biochem Soc Trans. 2008 Dec;36(Pt 6):1389-92. doi: 10.1042/BST0361389. Biochem Soc Trans. 2008. PMID: 19021561

5

Progeria, the nucleolus and farnesyltransferase inhibitors.

Mehta IS, Bridger JM, Kill IR. Mehta IS, et al. Among authors: kill ir. Biochem Soc Trans. 2010 Feb;38(Pt 1):287-91. doi: 10.1042/BST0380287. Biochem Soc Trans. 2010. PMID: 20074076

6

Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells.

Mehta IS, Eskiw CH, Arican HD, Kill IR, Bridger JM. Mehta IS, et al. Among authors: kill ir. Genome Biol. 2011 Aug 12;12(8):R74. doi: 10.1186/gb-2011-12-8-r74. Genome Biol. 2011. PMID: 21838864 Free PMC article.

7

Progeria Research Day at Brunel University.

Bridger JM, Eskiw CH, Makarov EM, Tree D, Kill IR. Bridger JM, et al. Among authors: kill ir. Nucleus. 2011 Nov-Dec;2(6):517-22. doi: 10.4161/nucl.2.6.17605. Epub 2011 Nov 1. Nucleus. 2011. PMID: 22064469 Free PMC article. Review.

8

A structured environment helps to regulate nuclear architecture in breast epithelial cells.

Bridger JM, Kill IR. Bridger JM, et al. Among authors: kill ir. Cell Cycle. 2016 May 2;15(9):1178-9. doi: 10.1080/15384101.2016.1147114. Epub 2016 Apr 14. Cell Cycle. 2016. PMID: 27078818 Free PMC article. No abstract available.

9

Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts.

Bikkul MU, Clements CS, Godwin LS, Goldberg MW, Kill IR, Bridger JM. Bikkul MU, et al. Among authors: kill ir. Biogerontology. 2018 Dec;19(6):579-602. doi: 10.1007/s10522-018-9758-4. Epub 2018 Jun 15. Biogerontology. 2018. PMID: 29907918 Free PMC article.

10

Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways.

Clements CS, Bikkul MU, Ofosu W, Eskiw C, Tree D, Makarov E, Kill IR, Bridger JM. Clements CS, et al. Among authors: kill ir. Biogerontology. 2019 Jun;20(3):337-358. doi: 10.1007/s10522-019-09807-4. Epub 2019 Apr 30. Biogerontology. 2019. PMID: 31041622 Free PMC article.

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