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ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy.
Veenstra VL, Damhofer H, Waasdorp C, van Rijssen LB, van de Vijver MJ, Dijk F, Wilmink HW, Besselink MG, Busch OR, Chang DK, Bailey PJ, Biankin AV, Kocher HM, Medema JP, Li JS, Jiang R, Pierce DW, van Laarhoven HWM, Bijlsma MF. Veenstra VL, et al. Among authors: kocher hm. Oncogenesis. 2018 Nov 16;7(11):87. doi: 10.1038/s41389-018-0096-9. Oncogenesis. 2018. PMID: 30442938 Free PMC article.
Stromal SPOCK1 supports invasive pancreatic cancer growth.
Veenstra VL, Damhofer H, Waasdorp C, Steins A, Kocher HM, Medema JP, van Laarhoven HW, Bijlsma MF. Veenstra VL, et al. Among authors: kocher hm. Mol Oncol. 2017 Aug;11(8):1050-1064. doi: 10.1002/1878-0261.12073. Epub 2017 Jun 5. Mol Oncol. 2017. PMID: 28486750 Free PMC article.
The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy.
Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB, Chang D, Bailey P, Scarpa A, Lawlor R, Chelala C, Keyse SM, Biankin A, Morton JP, Evans TJ, Barry ST, Sansom OJ, Kocher HM, Marshall JF. Reader CS, et al. Among authors: kocher hm. J Pathol. 2019 Nov;249(3):332-342. doi: 10.1002/path.5320. Epub 2019 Jul 30. J Pathol. 2019. PMID: 31259422 Free PMC article.
High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1.
Steins A, van Mackelenbergh MG, van der Zalm AP, Klaassen R, Serrels B, Goris SG, Kocher HM, Waasdorp C, de Jong JH, Tekin C, Besselink MG, Busch OR, van de Vijver MJ, Verheij J, Dijk F, van Tienhoven G, Wilmink JW, Medema JP, van Laarhoven HW, Bijlsma MF. Steins A, et al. Among authors: kocher hm. EMBO Rep. 2020 May 6;21(5):e48780. doi: 10.15252/embr.201948780. Epub 2020 Mar 16. EMBO Rep. 2020. PMID: 32173982 Free PMC article.
A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.
Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T, Marshall JF, Kocher HM, Crnogorac-Jurcevic T, Scarpa A, Lemoine NR, Chelala C. Haider S, et al. Among authors: kocher hm. Genome Med. 2014 Dec 3;6(12):105. doi: 10.1186/s13073-014-0105-3. eCollection 2014. Genome Med. 2014. PMID: 25587357 Free PMC article.
Pancreatic Cancer Organotypic Models.
Coetzee A, Grose R, Kocher H. Coetzee A, et al. Curr Top Microbiol Immunol. 2021;430:183-198. doi: 10.1007/82_2019_155. Curr Top Microbiol Immunol. 2021. PMID: 30790075
Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer.
Kocher HM, Basu B, Froeling FEM, Sarker D, Slater S, Carlin D, deSouza NM, De Paepe KN, Goulart MR, Hughes C, Imrali A, Roberts R, Pawula M, Houghton R, Lawrence C, Yogeswaran Y, Mousa K, Coetzee C, Sasieni P, Prendergast A, Propper DJ. Kocher HM, et al. Nat Commun. 2020 Sep 24;11(1):4841. doi: 10.1038/s41467-020-18636-w. Nat Commun. 2020. PMID: 32973176 Free PMC article. Clinical Trial.
Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice.
Delvecchio FR, Fincham REA, Spear S, Clear A, Roy-Luzarraga M, Balkwill FR, Gribben JG, Bombardieri M, Hodivala-Dilke K, Capasso M, Kocher HM. Delvecchio FR, et al. Among authors: kocher hm. Cell Mol Gastroenterol Hepatol. 2021;12(5):1543-1565. doi: 10.1016/j.jcmgh.2021.06.023. Epub 2021 Jul 9. Cell Mol Gastroenterol Hepatol. 2021. PMID: 34252585 Free PMC article.
190 results