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AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. Gwinn DM, et al. Among authors: shackelford db. Mol Cell. 2008 Apr 25;30(2):214-26. doi: 10.1016/j.molcel.2008.03.003. Mol Cell. 2008. PMID: 18439900 Free PMC article.
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ. Egan DF, et al. Among authors: shackelford db. Science. 2011 Jan 28;331(6016):456-61. doi: 10.1126/science.1196371. Epub 2010 Dec 23. Science. 2011. PMID: 21205641 Free PMC article.
Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.
Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Magyar C, Braas D, Graeber T, Jackson NJ, Czernin J, Emberley E, Gross M, Janes J, Mackinnon A, Pan A, Rodriguez M, Works M, Zhang W, Parlati F, Demo S, Garon E, Krysan K, Walser TC, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. Momcilovic M, et al. Among authors: shackelford db. Cell Rep. 2017 Jan 17;18(3):601-610. doi: 10.1016/j.celrep.2016.12.061. Cell Rep. 2017. PMID: 28099841 Free PMC article.
Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden.
Salehi-Rad R, Li R, Tran LM, Lim RJ, Abascal J, Momcilovic M, Park SJ, Ong SL, Shabihkhani M, Huang ZL, Paul M, Shackelford DB, Krysan K, Liu B, Dubinett SM. Salehi-Rad R, et al. Among authors: shackelford db. Cancer Immunol Immunother. 2021 Aug;70(8):2389-2400. doi: 10.1007/s00262-020-02837-9. Epub 2021 Jan 28. Cancer Immunol Immunother. 2021. PMID: 33507343 Free PMC article.
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.
Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. Krall AS, et al. Among authors: shackelford db. Cell Metab. 2021 May 4;33(5):1013-1026.e6. doi: 10.1016/j.cmet.2021.02.001. Epub 2021 Feb 19. Cell Metab. 2021. PMID: 33609439 Free PMC article.
52 results