Brust TF - Search Results

1

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists.

Tosh DK, Ciancetta A, Mannes P, Warnick E, Janowsky A, Eshleman AJ, Gizewski E, Brust TF, Bohn LM, Auchampach JA, Gao ZG, Jacobson KA. Tosh DK, et al. Among authors: brust tf. ACS Omega. 2018 Oct 31;3(10):12658-12678. doi: 10.1021/acsomega.8b01237. Epub 2018 Oct 4. ACS Omega. 2018. PMID: 30411015 Free PMC article.

2

Advances in Sulfonamide Kappa Opioid Receptor Antagonists: Structural Refinement and Evaluation of CNS Clearance.

Ma H, Brust T, Frankowski KJ, Lovell KM, Cameron MD, Bohn LM, Aubé J. Ma H, et al. ACS Chem Neurosci. 2022 Apr 20;13(8):1315-1332. doi: 10.1021/acschemneuro.2c00140. Epub 2022 Apr 11. ACS Chem Neurosci. 2022. PMID: 35410469

3

O6C-20-nor-salvinorin A is a stable and potent KOR agonist.

Hirasawa S, Cho M, Brust TF, Roach JJ, Bohn LM, Shenvi RA. Hirasawa S, et al. Among authors: brust tf. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2770-2772. doi: 10.1016/j.bmcl.2018.01.055. Epub 2018 Jan 31. Bioorg Med Chem Lett. 2018. PMID: 29426768 Free PMC article.

4

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria.

Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aubé J, Jones SR, Martin TJ, Bohn LM. Brust TF, et al. Sci Signal. 2016 Nov 29;9(456):ra117. doi: 10.1126/scisignal.aai8441. Sci Signal. 2016. PMID: 27899527 Free PMC article.

5

Biased agonism: An emerging paradigm in GPCR drug discovery.

Rankovic Z, Brust TF, Bohn LM. Rankovic Z, et al. Among authors: brust tf. Bioorg Med Chem Lett. 2016 Jan 15;26(2):241-250. doi: 10.1016/j.bmcl.2015.12.024. Epub 2015 Dec 9. Bioorg Med Chem Lett. 2016. PMID: 26707396 Free PMC article. Review.

6

Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.

Brust TF, Alongkronrusmee D, Soto-Velasquez M, Baldwin TA, Ye Z, Dai M, Dessauer CW, van Rijn RM, Watts VJ. Brust TF, et al. Sci Signal. 2017 Feb 21;10(467):eaah5381. doi: 10.1126/scisignal.aah5381. Sci Signal. 2017. PMID: 28223412 Free PMC article.

7

Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways.

Brust TF, Hayes MP, Roman DL, Burris KD, Watts VJ. Brust TF, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):480-93. doi: 10.1124/jpet.114.220293. Epub 2014 Dec 24. J Pharmacol Exp Ther. 2015. PMID: 25539635 Free PMC article.

8

Biased Ligands at the Kappa Opioid Receptor: Fine-Tuning Receptor Pharmacology.

Brust TF. Brust TF. Handb Exp Pharmacol. 2022;271:115-135. doi: 10.1007/164_2020_395. Handb Exp Pharmacol. 2022. PMID: 33140224 Review.

9

Palladium-catalyzed regio- and stereoselective γ-arylation of tertiary allylic amines: identification of potent adenylyl cyclase inhibitors.

Ye Z, Brust TF, Watts VJ, Dai M. Ye Z, et al. Among authors: brust tf. Org Lett. 2015 Feb 20;17(4):892-5. doi: 10.1021/ol503748t. Epub 2015 Feb 10. Org Lett. 2015. PMID: 25668690 Free PMC article.

10

Discovery of antagonists of tick dopamine receptors via chemical library screening and comparative pharmacological analyses.

Ejendal KF, Meyer JM, Brust TF, Avramova LV, Hill CA, Watts VJ. Ejendal KF, et al. Among authors: brust tf. Insect Biochem Mol Biol. 2012 Nov;42(11):846-53. doi: 10.1016/j.ibmb.2012.07.011. Insect Biochem Mol Biol. 2012. PMID: 23213654

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