Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells.
Hefzi H, Martínez-Monge I, Marin de Mas I, Cowie NL, Toledo AG, Noh SM, Karottki KJC, Decker M, Arnsdorf J, Camacho-Zaragoza JM, Kol S, Schoffelen S, Pristovšek N, Hansen AH, Miguez AA, Bjørn SP, Brøndum KK, Javidi EM, Jensen KL, Stangl L, Kreidl E, Kallehauge TB, Ley D, Ménard P, Petersen HM, Sukhova Z, Bauer A, Casanova E, Barron N, Malmström J, Nielsen LK, Lee GM, Kildegaard HF, Voldborg BG, Lewis NE.
Hefzi H, et al. Among authors: lee gm.
Nat Metab. 2025 Jan 14. doi: 10.1038/s42255-024-01193-7. Online ahead of print.
Nat Metab. 2025.
PMID: 39809975