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Disruption of VEGF Mediated Flk-1 Signaling Leads to a Gradual Loss of Vessel Health and Cardiac Function During Myocardial Infarction: Potential Therapy With Pellino-1.
Thirunavukkarasu M, Selvaraju V, Joshi M, Coca-Soliz V, Tapias L, Saad I, Fournier C, Husain A, Campbell J, Yee SP, Sanchez JA, Palesty JA, McFadden DW, Maulik N. Thirunavukkarasu M, et al. Among authors: selvaraju v. J Am Heart Assoc. 2018 Sep 18;7(18):e007601. doi: 10.1161/JAHA.117.007601. J Am Heart Assoc. 2018. PMID: 30371196 Free PMC article.
Thioredoxin-1 (Trx1) engineered mesenchymal stem cell therapy increased pro-angiogenic factors, reduced fibrosis and improved heart function in the infarcted rat myocardium.
Suresh SC, Selvaraju V, Thirunavukkarasu M, Goldman JW, Husain A, Alexander Palesty J, Sanchez JA, McFadden DW, Maulik N. Suresh SC, et al. Among authors: selvaraju v. Int J Cardiol. 2015 Dec 15;201:517-28. doi: 10.1016/j.ijcard.2015.08.117. Epub 2015 Aug 15. Int J Cardiol. 2015. PMID: 26322599
Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models.
Selvaraju V, Thirunavukkarasu M, Joshi M, Oriowo B, Shaikh IA, Rishi MT, Tapias L, Coca-Soliz V, Saad I, Campbell J, Pradeep SR, Swaminathan S, Yee SP, McFadden DW, Alexander Palesty J, Maulik N. Selvaraju V, et al. Basic Res Cardiol. 2020 Jun 14;115(4):45. doi: 10.1007/s00395-020-0804-4. Basic Res Cardiol. 2020. PMID: 32537701
Simvastatin treatment inhibits hypoxia inducible factor 1-alpha-(HIF-1alpha)-prolyl-4-hydroxylase 3 (PHD-3) and increases angiogenesis after myocardial infarction in streptozotocin-induced diabetic rat.
Thirunavukkarasu M, Selvaraju V, Dunna NR, Foye JL, Joshi M, Otani H, Maulik N. Thirunavukkarasu M, et al. Among authors: selvaraju v. Int J Cardiol. 2013 Oct 3;168(3):2474-80. doi: 10.1016/j.ijcard.2013.03.005. Epub 2013 Apr 13. Int J Cardiol. 2013. PMID: 23590933
49 results