Wang ZZ - Search Results

1

Identifying the novel inhibitors of lysine-specific demethylase 1 (LSD1) combining pharmacophore-based and structure-based virtual screening.

Sun XD, Zheng YC, Ma CY, Yang J, Gao QB, Yan Y, Wang ZZ, Li W, Zhao W, Liu HM, Ding L. Sun XD, et al. Among authors: wang zz. J Biomol Struct Dyn. 2019 Oct;37(16):4200-4214. doi: 10.1080/07391102.2018.1538903. Epub 2018 Dec 5. J Biomol Struct Dyn. 2019. PMID: 30366512

2

3D-QSAR (CoMFA, CoMSIA), molecular docking and molecular dynamics simulations study of 6-aryl-5-cyano-pyrimidine derivatives to explore the structure requirements of LSD1 inhibitors.

Ding L, Wang ZZ, Sun XD, Yang J, Ma CY, Li W, Liu HM. Ding L, et al. Among authors: wang zz. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3521-3528. doi: 10.1016/j.bmcl.2017.05.065. Epub 2017 May 24. Bioorg Med Chem Lett. 2017. PMID: 28610981

3

Probing the binding mechanism of substituted pyridine derivatives as effective and selective lysine-specific demethylase 1 inhibitors using 3D-QSAR, molecular docking and molecular dynamics simulations.

Wang ZZ, Yang J, Sun XD, Ma CY, Gao QB, Ding L, Liu HM. Wang ZZ, et al. J Biomol Struct Dyn. 2019 Aug;37(13):3482-3495. doi: 10.1080/07391102.2018.1518158. Epub 2018 Dec 5. J Biomol Struct Dyn. 2019. PMID: 30175693

4

Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction.

Wang S, Zhao L, Shi XJ, Ding L, Yang L, Wang ZZ, Shen D, Tang K, Li XJ, Mamun M, Li H, Yu B, Zheng YC, Wang S, Liu HM. Wang S, et al. Among authors: wang zz. J Med Chem. 2019 Mar 14;62(5):2772-2797. doi: 10.1021/acs.jmedchem.9b00113. Epub 2019 Mar 4. J Med Chem. 2019. PMID: 30803229

5

Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A).

Li Z, Ding L, Li Z, Wang Z, Suo F, Shen D, Zhao T, Sun X, Wang J, Liu Y, Ma L, Zhao B, Geng P, Yu B, Zheng Y, Liu H. Li Z, et al. Acta Pharm Sin B. 2019 Jul;9(4):794-808. doi: 10.1016/j.apsb.2019.01.001. Epub 2019 Jan 5. Acta Pharm Sin B. 2019. PMID: 31384539 Free PMC article.

6

Structure-guided discovery of novel dUTPase inhibitors with anti-Nocardia activity by computational design.

Wang ZZ, Weng J, Qi J, Fu XX, Xing BB, Hu Y, Huang CH, Chen CY, Wei Z. Wang ZZ, et al. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2411573. doi: 10.1080/14756366.2024.2411573. Epub 2024 Oct 10. J Enzyme Inhib Med Chem. 2024. PMID: 39390714 Free PMC article.

7

Web support for the more efficient discovery of kinase inhibitors.

Chen Y, Wang ZZ, Hao GF, Song BA. Chen Y, et al. Among authors: wang zz. Drug Discov Today. 2022 Aug;27(8):2216-2225. doi: 10.1016/j.drudis.2022.04.002. Epub 2022 Apr 7. Drug Discov Today. 2022. PMID: 35398561 Review.

8

Exploring the kinase-inhibitor fragment interaction space facilitates the discovery of kinase inhibitor overcoming resistance by mutations.

Wang ZZ, Wang MS, Wang F, Shi XX, Huang W, Hao GF, Yang GF. Wang ZZ, et al. Among authors: wang f, wang ms. Brief Bioinform. 2022 Jul 18;23(4):bbac203. doi: 10.1093/bib/bbac203. Brief Bioinform. 2022. PMID: 35649390

9

Discovery of Macrocycle-Based HPK1 Inhibitors for T-Cell-Based Immunotherapy.

Wang MS, Wang ZZ, Li ZL, Gong Y, Duan CX, Cheng QH, Huang W, Yang GF. Wang MS, et al. Among authors: wang zz. J Med Chem. 2023 Jan 12;66(1):611-626. doi: 10.1021/acs.jmedchem.2c01551. Epub 2022 Dec 21. J Med Chem. 2023. PMID: 36542759

10

Fragment-based drug design facilitates selective kinase inhibitor discovery.

Wang ZZ, Shi XX, Huang GY, Hao GF, Yang GF. Wang ZZ, et al. Trends Pharmacol Sci. 2021 Jul;42(7):551-565. doi: 10.1016/j.tips.2021.04.001. Epub 2021 May 3. Trends Pharmacol Sci. 2021. PMID: 33958239 Review.

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