Fang Z - Search Results

1

Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.

Zhang J, Murugan NA, Tian Y, Bertagnin C, Fang Z, Kang D, Kong X, Jia H, Sun Z, Jia R, Gao P, Poongavanam V, Loregian A, Xu W, Ma X, Ding X, Huang B, Zhan P, Liu X. Zhang J, et al. Among authors: fang z. J Med Chem. 2018 Nov 21;61(22):9976-9999. doi: 10.1021/acs.jmedchem.8b01065. Epub 2018 Nov 6. J Med Chem. 2018. PMID: 30365885

2

Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies.

Zhan P, Liu X, Li Z, Fang Z, Li Z, Wang D, Pannecouque C, Clercq ED. Zhan P, et al. Among authors: fang z. Bioorg Med Chem. 2009 Aug 15;17(16):5920-7. doi: 10.1016/j.bmc.2009.07.004. Epub 2009 Jul 7. Bioorg Med Chem. 2009. PMID: 19620009

3

Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Zhan P, Liu X, Fang Z, Li Z, Pannecouque C, De Clercq E. Zhan P, et al. Among authors: fang z. Eur J Med Chem. 2009 Nov;44(11):4648-53. doi: 10.1016/j.ejmech.2009.06.037. Epub 2009 Jul 4. Eur J Med Chem. 2009. PMID: 19628308

4

Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Zhan P, Liu X, Zhu J, Fang Z, Li Z, Pannecouque C, Clercq ED. Zhan P, et al. Among authors: fang z. Bioorg Med Chem. 2009 Aug 15;17(16):5775-81. doi: 10.1016/j.bmc.2009.07.028. Epub 2009 Jul 18. Bioorg Med Chem. 2009. PMID: 19643613

5

1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation.

Zhan P, Liu X, Fang Z, Pannecouque C, De Clercq E. Zhan P, et al. Among authors: fang z. Bioorg Med Chem. 2009 Sep 1;17(17):6374-9. doi: 10.1016/j.bmc.2009.07.027. Epub 2009 Jul 18. Bioorg Med Chem. 2009. PMID: 19647440

6

1,2,3-thiadiazole thioacetanilides. Part 2: Synthesis and biological evaluation of a new series of 2-{[4-(3,4-dichlorophenyl)-1,2,3-thiadiazol-5-yl]sulfanyl}acetanilides as HIV-1 inhibitors.

Zhan P, Liu XY, Li ZY, Fang ZJ, Pannecouque C, De Clercq E. Zhan P, et al. Chem Biodivers. 2010 Jul;7(7):1717-27. doi: 10.1002/cbdv.200900197. Chem Biodivers. 2010. PMID: 20658659

7

HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and implications for drug design.

Zhan P, Chen X, Li D, Fang Z, De Clercq E, Liu X. Zhan P, et al. Among authors: fang z. Med Res Rev. 2013 Jun;33 Suppl 1:E1-72. doi: 10.1002/med.20241. Epub 2011 Apr 26. Med Res Rev. 2013. PMID: 21523792 Review.

8

Recent advances in the discovery and development of novel HIV-1 NNRTI platforms (Part II): 2009-2013 update.

Song Y, Fang Z, Zhan P, Liu X. Song Y, et al. Among authors: fang z. Curr Med Chem. 2014;21(3):329-55. doi: 10.2174/09298673113206660298. Curr Med Chem. 2014. PMID: 24164196 Review.

9

Conformational restriction: an effective tactic in 'follow-on'-based drug discovery.

Fang Z, Song Y, Zhan P, Zhang Q, Liu X. Fang Z, et al. Future Med Chem. 2014 May;6(8):885-901. doi: 10.4155/fmc.14.50. Future Med Chem. 2014. PMID: 24962281 Review.

10

Synthesis and Preliminary Antiviral Activities of Piperidine-substituted Purines against HIV and Influenza A/H1N1 Infections.

Kang D, Fang Z, Huang B, Zhang L, Liu H, Pannecouque C, Naesens L, De Clercq E, Zhan P, Liu X. Kang D, et al. Among authors: fang z. Chem Biol Drug Des. 2015 Oct;86(4):568-77. doi: 10.1111/cbdd.12520. Epub 2015 Feb 6. Chem Biol Drug Des. 2015. PMID: 25600073

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