Guan KL - Search Results

1

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.

Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. Badur MG, et al. Among authors: guan kl. Cell Rep. 2018 Oct 23;25(4):1018-1026.e4. doi: 10.1016/j.celrep.2018.09.074. Cell Rep. 2018. PMID: 30355481 Free PMC article.

2

R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis.

Ye D, Ma S, Xiong Y, Guan KL. Ye D, et al. Among authors: guan kl. Cancer Cell. 2013 Mar 18;23(3):274-6. doi: 10.1016/j.ccr.2013.03.005. Cancer Cell. 2013. PMID: 23518346 Free PMC article.

3

WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation.

Wang Y, Xiao M, Chen X, Chen L, Xu Y, Lv L, Wang P, Yang H, Ma S, Lin H, Jiao B, Ren R, Ye D, Guan KL, Xiong Y. Wang Y, et al. Among authors: guan kl. Mol Cell. 2015 Feb 19;57(4):662-673. doi: 10.1016/j.molcel.2014.12.023. Epub 2015 Jan 15. Mol Cell. 2015. PMID: 25601757 Free PMC article.

4

D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth.

Ma S, Jiang B, Deng W, Gu ZK, Wu FZ, Li T, Xia Y, Yang H, Ye D, Xiong Y, Guan KL. Ma S, et al. Among authors: guan kl. Oncotarget. 2015 Apr 20;6(11):8606-20. doi: 10.18632/oncotarget.3330. Oncotarget. 2015. PMID: 25825982 Free PMC article.

5

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents.

Wang P, Wu J, Ma S, Zhang L, Yao J, Hoadley KA, Wilkerson MD, Perou CM, Guan KL, Ye D, Xiong Y. Wang P, et al. Among authors: guan kl. Cell Rep. 2015 Dec 22;13(11):2353-2361. doi: 10.1016/j.celrep.2015.11.029. Epub 2015 Dec 10. Cell Rep. 2015. PMID: 26686626 Free PMC article.

6

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense.

Zhou L, Wang F, Sun R, Chen X, Zhang M, Xu Q, Wang Y, Wang S, Xiong Y, Guan KL, Yang P, Yu H, Ye D. Zhou L, et al. Among authors: guan kl. EMBO Rep. 2016 Jun;17(6):811-22. doi: 10.15252/embr.201541643. Epub 2016 Apr 9. EMBO Rep. 2016. PMID: 27113762 Free PMC article.

7

L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration.

Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, Guan KL. Ma S, et al. Among authors: guan kl. Mol Cell Biol. 2017 Mar 31;37(8):e00492-16. doi: 10.1128/MCB.00492-16. Print 2017 Apr 15. Mol Cell Biol. 2017. PMID: 28137912 Free PMC article.

8

Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates.

Ye D, Guan KL, Xiong Y. Ye D, et al. Among authors: guan kl. Trends Cancer. 2018 Feb;4(2):151-165. doi: 10.1016/j.trecan.2017.12.005. Epub 2018 Jan 5. Trends Cancer. 2018. PMID: 29458964 Free PMC article. Review.

9

The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell.

Plouffe SW, Lin KC, Moore JL 3rd, Tan FE, Ma S, Ye Z, Qiu Y, Ren B, Guan KL. Plouffe SW, et al. Among authors: guan kl. J Biol Chem. 2018 Jul 13;293(28):11230-11240. doi: 10.1074/jbc.RA118.002715. Epub 2018 May 25. J Biol Chem. 2018. PMID: 29802201 Free PMC article.

10

Polycystic kidney disease: a Hippo connection.

Ma S, Guan KL. Ma S, et al. Among authors: guan kl. Genes Dev. 2018 Jun 1;32(11-12):737-739. doi: 10.1101/gad.316570.118. Genes Dev. 2018. PMID: 29921661 Free PMC article. Review.

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