Burke JE - Search Results

1

Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii.

Powell CJ, Ramaswamy R, Kelsen A, Hamelin DJ, Warshaw DM, Bosch J, Burke JE, Ward GE, Boulanger MJ. Powell CJ, et al. Among authors: burke je. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10548-E10555. doi: 10.1073/pnas.1811167115. Epub 2018 Oct 22. Proc Natl Acad Sci U S A. 2018. PMID: 30348763 Free PMC article.

2

Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.

Dornan GL, Siempelkamp BD, Jenkins ML, Vadas O, Lucas CL, Burke JE. Dornan GL, et al. Among authors: burke je. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1982-1987. doi: 10.1073/pnas.1617244114. Epub 2017 Feb 6. Proc Natl Acad Sci U S A. 2017. PMID: 28167755 Free PMC article.

3

Dissecting the molecular assembly of the Toxoplasma gondii MyoA motility complex.

Powell CJ, Jenkins ML, Parker ML, Ramaswamy R, Kelsen A, Warshaw DM, Ward GE, Burke JE, Boulanger MJ. Powell CJ, et al. Among authors: burke je. J Biol Chem. 2017 Nov 24;292(47):19469-19477. doi: 10.1074/jbc.M117.809632. Epub 2017 Sep 25. J Biol Chem. 2017. PMID: 28972141 Free PMC article.

4

Conformational sampling of membranes by Akt controls its activation and inactivation.

Lučić I, Rathinaswamy MK, Truebestein L, Hamelin DJ, Burke JE, Leonard TA. Lučić I, et al. Among authors: burke je. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3940-E3949. doi: 10.1073/pnas.1716109115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632185 Free PMC article.

5

Probing the Architecture, Dynamics, and Inhibition of the PI4KIIIα/TTC7/FAM126 Complex.

Dornan GL, Dalwadi U, Hamelin DJ, Hoffmann RM, Yip CK, Burke JE. Dornan GL, et al. Among authors: burke je. J Mol Biol. 2018 Sep 14;430(18 Pt B):3129-3142. doi: 10.1016/j.jmb.2018.07.020. Epub 2018 Jul 18. J Mol Biol. 2018. PMID: 30031006

6

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

Jenkins ML, Margaria JP, Stariha JTB, Hoffmann RM, McPhail JA, Hamelin DJ, Boulanger MJ, Hirsch E, Burke JE. Jenkins ML, et al. Among authors: burke je. Nat Commun. 2018 Sep 14;9(1):3772. doi: 10.1038/s41467-018-06196-z. Nat Commun. 2018. PMID: 30217979 Free PMC article.

7

Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester.

Castro-Falcón G, Seiler GS, Demir Ö, Rathinaswamy MK, Hamelin D, Hoffmann RM, Makowski SL, Letzel AC, Field SJ, Burke JE, Amaro RE, Hughes CC. Castro-Falcón G, et al. Among authors: burke je. J Med Chem. 2018 Dec 13;61(23):10463-10472. doi: 10.1021/acs.jmedchem.8b00975. Epub 2018 Nov 28. J Med Chem. 2018. PMID: 30380865 Free PMC article.

8

A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion.

Heitz SD, Hamelin DJ, Hoffmann RM, Greenberg N, Salloum G, Erami Z, Khalil BD, Shymanets A, Steidle EA, Gong GQ, Nürnberg B, Burke JE, Flanagan JU, Bresnick AR, Backer JM. Heitz SD, et al. Among authors: burke je. J Biol Chem. 2019 Mar 22;294(12):4621-4633. doi: 10.1074/jbc.RA118.006032. Epub 2019 Jan 18. J Biol Chem. 2019. PMID: 30659094 Free PMC article.

9

The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme.

Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA. Shanbhogue P, et al. Among authors: burke je. J Biol Chem. 2019 May 3;294(18):7488-7502. doi: 10.1074/jbc.RA118.007288. Epub 2019 Mar 19. J Biol Chem. 2019. PMID: 30890560 Free PMC article.

10

Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication.

McPhail JA, Lyoo H, Pemberton JG, Hoffmann RM, van Elst W, Strating JRPM, Jenkins ML, Stariha JTB, Powell CJ, Boulanger MJ, Balla T, van Kuppeveld FJM, Burke JE. McPhail JA, et al. Among authors: burke je. EMBO Rep. 2020 Feb 5;21(2):e48441. doi: 10.15252/embr.201948441. Epub 2019 Dec 12. EMBO Rep. 2020. PMID: 31829496 Free PMC article.

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