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BTK inhibition ameliorates kidney disease in spontaneous lupus nephritis.
Chalmers SA, Glynn E, Garcia SJ, Panzenbeck M, Pelletier J, Dimock J, Seccareccia E, Bosanac T, Khalil S, Harcken C, Webb D, Nabozny G, Fine JS, Souza D, Klein E, Herlitz L, Ramanujam M, Putterman C. Chalmers SA, et al. Among authors: klein e. Clin Immunol. 2018 Dec;197:205-218. doi: 10.1016/j.clim.2018.10.008. Epub 2018 Oct 16. Clin Immunol. 2018. PMID: 30339790 Free PMC article.
Safety, pharmacokinetics and pharmacodynamics of BI 705564, a highly selective, covalent inhibitor of Bruton's tyrosine kinase, in Phase I clinical trials in healthy volunteers.
Litzenburger T, Steffgen J, Benediktus E, Müller F, Schultz A, Klein E, Ramanujam M, Harcken C, Gupta A, Wu J, Wiebe S, Li X, Flack M, Padula SJ, Visvanathan S, Hünnemeyer A, Hui J. Litzenburger T, et al. Among authors: klein e. Br J Clin Pharmacol. 2021 Apr;87(4):1824-1838. doi: 10.1111/bcp.14571. Epub 2020 Nov 20. Br J Clin Pharmacol. 2021. PMID: 32986868 Free PMC article. Clinical Trial.
N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity.
Abeywardane A, Caviness G, Choi Y, Cogan D, Gao A, Goldberg D, Heim-Riether A, Jeanfavre D, Klein E, Kowalski JA, Mao W, Miller C, Moss N, Ramsden P, Raymond E, Skow D, Smith-Keenan L, Snow RJ, Wu F, Wu JP, Yu Y. Abeywardane A, et al. Among authors: klein e. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283. doi: 10.1016/j.bmcl.2016.09.047. Epub 2016 Sep 21. Bioorg Med Chem Lett. 2016. PMID: 27692854 Free article.
Estimated Vaccine Effectiveness for Pediatric Patients With Severe Influenza, 2015-2020.
Sumner KM, Sahni LC, Boom JA, Halasa NB, Stewart LS, Englund JA, Klein EJ, Staat MA, Schlaudecker EP, Selvarangan R, Harrison CJ, Weinberg GA, Szilagyi PG, Singer MN, Azimi PH, Clopper BR, Moline HL, Noble EK, Williams JV, Michaels MG, Olson SM; New Vaccine Surveillance Network Collaborators. Sumner KM, et al. Among authors: klein ej. JAMA Netw Open. 2024 Dec 2;7(12):e2452512. doi: 10.1001/jamanetworkopen.2024.52512. JAMA Netw Open. 2024. PMID: 39729317 Free PMC article.
3,532 results