Hunter AK - Search Results

1

Cathepsin L Causes Proteolytic Cleavage of Chinese-Hamster-Ovary Cell Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation.

Luo H, Tie L, Cao M, Hunter AK, Pabst TM, Du J, Field R, Li Y, Wang WK. Luo H, et al. Among authors: hunter ak. Biotechnol Prog. 2019 Jan;35(1):e2732. doi: 10.1002/btpr.2732. Epub 2018 Nov 4. Biotechnol Prog. 2019. PMID: 30320962 Free PMC article.

2

Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor clearance of host cell proteins by protein A chromatography.

Luo H, Du Q, Qian C, Mlynarczyk M, Pabst TM, Damschroder M, Hunter AK, Wang WK. Luo H, et al. Among authors: hunter ak. J Chromatogr A. 2022 Aug 30;1679:463385. doi: 10.1016/j.chroma.2022.463385. Epub 2022 Jul 30. J Chromatogr A. 2022. PMID: 35933770

3

A systematic approach for analysis and characterization of mispairing in bispecific antibodies with asymmetric architecture.

Wang C, Vemulapalli B, Cao M, Gadre D, Wang J, Hunter A, Wang X, Liu D. Wang C, et al. MAbs. 2018 Nov-Dec;10(8):1226-1235. doi: 10.1080/19420862.2018.1511198. Epub 2018 Sep 20. MAbs. 2018. PMID: 30153083 Free PMC article.

4

Process-scale purification and analytical characterization of highly gamma-carboxylated recombinant human prothrombin.

Wendeler M, Pabst TM, Wang J, Strouse RJ, Wang X, Hunter AK. Wendeler M, et al. Among authors: hunter ak. J Chromatogr A. 2014 Jan 17;1325:171-8. doi: 10.1016/j.chroma.2013.12.024. Epub 2013 Dec 15. J Chromatogr A. 2014. PMID: 24369997

5

Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin.

Linke T, Aspelund MT, Thompson C, Xi G, Fulton A, Wendeler M, Pabst TM, Wang X, Wang WK, Ram K, Hunter AK. Linke T, et al. Among authors: hunter ak. Biotechnol Prog. 2014 Nov-Dec;30(6):1380-9. doi: 10.1002/btpr.1983. Epub 2014 Sep 2. Biotechnol Prog. 2014. PMID: 25139260 Free PMC article.

6

Engineering of novel Staphylococcal Protein A ligands to enable milder elution pH and high dynamic binding capacity.

Pabst TM, Palmgren R, Forss A, Vasic J, Fonseca M, Thompson C, Wang WK, Wang X, Hunter AK. Pabst TM, et al. Among authors: hunter ak. J Chromatogr A. 2014 Oct 3;1362:180-5. doi: 10.1016/j.chroma.2014.08.046. Epub 2014 Aug 19. J Chromatogr A. 2014. PMID: 25193170 Free article.

7

Adsorption equilibrium and kinetics of monomer-dimer monoclonal antibody mixtures on a cation exchange resin.

Reck JM, Pabst TM, Hunter AK, Wang X, Carta G. Reck JM, et al. Among authors: hunter ak. J Chromatogr A. 2015 Jul 10;1402:46-59. doi: 10.1016/j.chroma.2015.05.007. Epub 2015 May 23. J Chromatogr A. 2015. PMID: 26028510

8

Camelid V_H H affinity ligands enable separation of closely related biopharmaceuticals.

Pabst TM, Wendeler M, Wang X, Bezemer S, Hermans P, Hunter AK. Pabst TM, et al. Among authors: hunter ak. Biotechnol J. 2017 Feb;12(2):1600357. doi: 10.1002/biot.201600357. Epub 2016 Oct 20. Biotechnol J. 2017. PMID: 27677057 Free PMC article.

9

Liquid-liquid phase separation causes high turbidity and pressure during low pH elution process in Protein A chromatography.

Luo H, Lee N, Wang X, Li Y, Schmelzer A, Hunter AK, Pabst T, Wang WK. Luo H, et al. Among authors: hunter ak. J Chromatogr A. 2017 Mar 10;1488:57-67. doi: 10.1016/j.chroma.2017.01.067. Epub 2017 Jan 28. J Chromatogr A. 2017. PMID: 28159365 Free article.

10

Evaluation of recent Protein A stationary phase innovations for capture of biotherapeutics.

Pabst TM, Thai J, Hunter AK. Pabst TM, et al. Among authors: hunter ak. J Chromatogr A. 2018 Jun 15;1554:45-60. doi: 10.1016/j.chroma.2018.03.060. Epub 2018 Apr 7. J Chromatogr A. 2018. PMID: 29685337 Free article.

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