Brooks CL - Search Results

1

Immunological Functions and Evolutionary Emergence of Heavy-Chain Antibodies.

Brooks CL, Rossotti MA, Henry KA. Brooks CL, et al. Trends Immunol. 2018 Dec;39(12):956-960. doi: 10.1016/j.it.2018.09.008. Epub 2018 Oct 10. Trends Immunol. 2018. PMID: 30314850 Review.

2

Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6.

Aguilar EN, Sagar S, Murray BR, Rajesh C, Lei EK, Michaud SA, Goodlett DR, Caffrey TC, Grandgenett PM, Swanson B, Brooks TM, Black AR, van Faassen H, Hussack G, Henry KA, Hollingsworth MA, Brooks CL, Radhakrishnan P. Aguilar EN, et al. Among authors: brooks tm, brooks cl. Mol Cancer Ther. 2024 Jun 4;23(6):836-853. doi: 10.1158/1535-7163.MCT-23-0868. Mol Cancer Ther. 2024. PMID: 38394685 Free PMC article.

3

Structure of a V_HH isolated from a naïve phage display library.

White B, Huh I, Brooks CL. White B, et al. Among authors: brooks cl. BMC Res Notes. 2019 Mar 19;12(1):154. doi: 10.1186/s13104-019-4197-0. BMC Res Notes. 2019. PMID: 30890176 Free PMC article.

4

Role of a noncanonical disulfide bond in the stability, affinity, and flexibility of a VHH specific for the Listeria virulence factor InlB.

Mendoza MN, Jian M, King MT, Brooks CL. Mendoza MN, et al. Among authors: brooks cl. Protein Sci. 2020 Apr;29(4):1004-1017. doi: 10.1002/pro.3831. Epub 2020 Feb 8. Protein Sci. 2020. PMID: 31981247 Free PMC article.

5

Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude.

Haji-Ghassemi O, Müller-Loennies S, Brooks CL, MacKenzie CR, Caveney N, Van Petegem F, Brade L, Kosma P, Brade H, Evans SV. Haji-Ghassemi O, et al. Among authors: brooks cl. Biochemistry. 2019 Feb 12;58(6):714-726. doi: 10.1021/acs.biochem.8b00318. Epub 2019 Jan 10. Biochemistry. 2019. PMID: 30571096

6

Crystal structure of a human MUC16 SEA domain reveals insight into the nature of the CA125 tumor marker.

White B, Patterson M, Karnwal S, Brooks CL. White B, et al. Among authors: brooks cl. Proteins. 2022 May;90(5):1210-1218. doi: 10.1002/prot.26303. Epub 2022 Jan 25. Proteins. 2022. PMID: 35037700 Free PMC article.

7

In situ proteolysis, crystallization and preliminary X-ray diffraction analysis of a VHH that binds listeria internalin B.

Huh I, Gene R, Kumaran J, MacKenzie CR, Brooks CL. Huh I, et al. Among authors: brooks cl. Acta Crystallogr F Struct Biol Commun. 2014 Nov;70(Pt 11):1532-5. doi: 10.1107/S2053230X1402010X. Epub 2014 Oct 25. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 25372824 Free PMC article.

8

Structural basis of V_HH-mediated neutralization of the food-borne pathogen Listeria monocytogenes.

King MT, Huh I, Shenai A, Brooks TM, Brooks CL. King MT, et al. Among authors: brooks tm, brooks cl. J Biol Chem. 2018 Aug 31;293(35):13626-13635. doi: 10.1074/jbc.RA118.003888. Epub 2018 Jul 5. J Biol Chem. 2018. PMID: 29976754 Free PMC article.

9

Glycosylation of MUC1 influences the binding of a therapeutic antibody by altering the conformational equilibrium of the antigen.

Movahedin M, Brooks TM, Supekar NT, Gokanapudi N, Boons GJ, Brooks CL. Movahedin M, et al. Among authors: brooks tm, brooks cl. Glycobiology. 2017 Jul 1;27(7):677-687. doi: 10.1093/glycob/cww131. Glycobiology. 2017. PMID: 28025250 Free PMC article.

10

A common NH53K mutation in the combining site of antibodies raised against chlamydial LPS glycoconjugates significantly increases avidity.

Blackler RJ, Müller-Loennies S, Brooks CL, Evans DW, Brade L, Kosma P, Brade H, Evans SV. Blackler RJ, et al. Among authors: brooks cl. Biochemistry. 2011 Apr 26;50(16):3357-68. doi: 10.1021/bi101886v. Epub 2011 Apr 1. Biochemistry. 2011. PMID: 21405106

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