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The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak.
Cao X, Yap JL, Newell-Rogers MK, Peddaboina C, Jiang W, Papaconstantinou HT, Jupitor D, Rai A, Jung KY, Tubin RP, Yu W, Vanommeslaeghe K, Wilder PT, MacKerell AD Jr, Fletcher S, Smythe RW. Cao X, et al. Among authors: peddaboina c. Mol Cancer. 2013 May 16;12(1):42. doi: 10.1186/1476-4598-12-42. Mol Cancer. 2013. PMID: 23680104 Free PMC article.
Mast cells and histamine are triggering the NF-κB-mediated reactions of adult and aged perilymphatic mesenteric tissues to acute inflammation.
Nizamutdinova IT, Dusio GF, Gasheva OY, Skoog H, Tobin R, Peddaboina C, Meininger CJ, Zawieja DC, Newell-Rogers MK, Gashev AA. Nizamutdinova IT, et al. Among authors: peddaboina c. Aging (Albany NY). 2016 Nov 21;8(11):3065-3090. doi: 10.18632/aging.101113. Aging (Albany NY). 2016. PMID: 27875806 Free PMC article.
Characterization of bortezomib-adapted I-45 mesothelioma cells.
Zhang L, Littlejohn JE, Cui Y, Cao X, Peddaboina C, Smythe WR. Zhang L, et al. Among authors: peddaboina c. Mol Cancer. 2010 May 18;9:110. doi: 10.1186/1476-4598-9-110. Mol Cancer. 2010. PMID: 20482802 Free PMC article.