Botta M - Search Results

1

Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment.

Molinari A, Fallacara AL, Di Maria S, Zamperini C, Poggialini F, Musumeci F, Schenone S, Angelucci A, Colapietro A, Crespan E, Kissova M, Maga G, Botta M. Molinari A, et al. Among authors: botta m. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3454-3457. doi: 10.1016/j.bmcl.2018.09.024. Epub 2018 Sep 20. Bioorg Med Chem Lett. 2018. PMID: 30262428

2

Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells.

Carraro F, Pucci A, Naldini A, Schenone S, Bruno O, Ranise A, Bondavalli F, Brullo C, Fossa P, Menozzi G, Mosti L, Manetti F, Botta M. Carraro F, et al. Among authors: botta m. J Med Chem. 2004 Mar 25;47(7):1595-8. doi: 10.1021/jm034257u. J Med Chem. 2004. PMID: 15027847

3

Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation.

Carraro F, Naldini A, Pucci A, Locatelli GA, Maga G, Schenone S, Bruno O, Ranise A, Bondavalli F, Brullo C, Fossa P, Menozzi G, Mosti L, Modugno M, Tintori C, Manetti F, Botta M. Carraro F, et al. Among authors: botta m. J Med Chem. 2006 Mar 9;49(5):1549-61. doi: 10.1021/jm050603r. J Med Chem. 2006. PMID: 16509573

4

Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors.

Mugnaini C, Manetti F, Esté JA, Clotet-Codina I, Maga G, Cancio R, Botta M, Corelli F. Mugnaini C, et al. Among authors: botta m. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3541-4. doi: 10.1016/j.bmcl.2006.03.080. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621553

5

A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors.

Manetti F, Locatelli GA, Maga G, Schenone S, Modugno M, Forli S, Corelli F, Botta M. Manetti F, et al. Among authors: botta m. J Med Chem. 2006 Jun 1;49(11):3278-86. doi: 10.1021/jm060236z. J Med Chem. 2006. PMID: 16722646

6

Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice.

Manetti F, Santucci A, Locatelli GA, Maga G, Spreafico A, Serchi T, Orlandini M, Bernardini G, Caradonna NP, Spallarossa A, Brullo C, Schenone S, Bruno O, Ranise A, Bondavalli F, Hoffmann O, Bologna M, Angelucci A, Botta M. Manetti F, et al. Among authors: botta m. J Med Chem. 2007 Nov 15;50(23):5579-88. doi: 10.1021/jm061449r. Epub 2007 Oct 11. J Med Chem. 2007. PMID: 17929792

7

Synthetic SRC-kinase domain inhibitors and their structural requirements.

Schenone S, Manetti F, Botta M. Schenone S, et al. Among authors: botta m. Anticancer Agents Med Chem. 2007 Nov;7(6):660-80. doi: 10.2174/187152007784111269. Anticancer Agents Med Chem. 2007. PMID: 18045061

8

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents.

Radi M, Crespan E, Botta G, Falchi F, Maga G, Manetti F, Corradi V, Mancini M, Santucci MA, Schenone S, Botta M. Radi M, et al. Among authors: botta m, botta g. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1207-11. doi: 10.1016/j.bmcl.2007.11.112. Epub 2007 Dec 4. Bioorg Med Chem Lett. 2008. PMID: 18078752

9

Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines.

Manetti F, Brullo C, Magnani M, Mosci F, Chelli B, Crespan E, Schenone S, Naldini A, Bruno O, Trincavelli ML, Maga G, Carraro F, Martini C, Bondavalli F, Botta M. Manetti F, et al. Among authors: botta m. J Med Chem. 2008 Mar 13;51(5):1252-9. doi: 10.1021/jm701240c. Epub 2008 Feb 8. J Med Chem. 2008. PMID: 18257513

10

Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines.

Schenone S, Brullo C, Bruno O, Bondavalli F, Mosti L, Maga G, Crespan E, Carraro F, Manetti F, Tintori C, Botta M. Schenone S, et al. Among authors: botta m. Eur J Med Chem. 2008 Dec;43(12):2665-76. doi: 10.1016/j.ejmech.2008.01.034. Epub 2008 Feb 6. Eur J Med Chem. 2008. PMID: 18342402

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