van Veldhoven JPD - Search Results

1

Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2.

Ortiz Zacarías NV, van Veldhoven JPD, Portner L, van Spronsen E, Ullo S, Veenhuizen M, van der Velden WJC, Zweemer AJM, Kreekel RM, Oenema K, Lenselink EB, Heitman LH, IJzerman AP. Ortiz Zacarías NV, et al. Among authors: van der velden wjc, van spronsen e, van veldhoven jpd. J Med Chem. 2018 Oct 25;61(20):9146-9161. doi: 10.1021/acs.jmedchem.8b00605. Epub 2018 Oct 11. J Med Chem. 2018. PMID: 30256641 Free PMC article.

2

A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines.

van Veldhoven JP, Chang LC, von Frijtag Drabbe Künzel JK, Mulder-Krieger T, Struensee-Link R, Beukers MW, Brussee J, IJzerman AP. van Veldhoven JP, et al. Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. doi: 10.1016/j.bmc.2008.01.013. Epub 2008 Jan 12. Bioorg Med Chem. 2008. PMID: 18258439

3

2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists.

Mantri M, de Graaf O, van Veldhoven J, Göblyös A, von Frijtag Drabbe Künzel JK, Mulder-Krieger T, Link R, de Vries H, Beukers MW, Brussee J, Ijzerman AP. Mantri M, et al. J Med Chem. 2008 Aug 14;51(15):4449-55. doi: 10.1021/jm701594y. Epub 2008 Jul 19. J Med Chem. 2008. PMID: 18637670

4

False positives in a reporter gene assay: identification and synthesis of substituted N-pyridin-2-ylbenzamides as competitive inhibitors of firefly luciferase.

Heitman LH, van Veldhoven JP, Zweemer AM, Ye K, Brussee J, IJzerman AP. Heitman LH, et al. J Med Chem. 2008 Aug 14;51(15):4724-9. doi: 10.1021/jm8004509. Epub 2008 Jul 23. J Med Chem. 2008. PMID: 18646744

5

A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor.

Heitman LH, Göblyös A, Zweemer AM, Bakker R, Mulder-Krieger T, van Veldhoven JP, de Vries H, Brussee J, Ijzerman AP. Heitman LH, et al. J Med Chem. 2009 Feb 26;52(4):926-31. doi: 10.1021/jm8014052. J Med Chem. 2009. PMID: 19161279

6

Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).

van Veldhoven JP, Blad CC, Artsen CM, Klopman C, Wolfram DR, Abdelkadir MJ, Lane JR, Brussee J, Ijzerman AP. van Veldhoven JP, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2736-9. doi: 10.1016/j.bmcl.2010.11.091. Epub 2010 Nov 25. Bioorg Med Chem Lett. 2011. PMID: 21167710

7

Novel 3,6,7-substituted pyrazolopyrimidines as positive allosteric modulators for the hydroxycarboxylic acid receptor 2 (GPR109A).

Blad CC, van Veldhoven JP, Klopman C, Wolfram DR, Brussee J, Lane JR, Ijzerman AP. Blad CC, et al. J Med Chem. 2012 Apr 12;55(7):3563-7. doi: 10.1021/jm300164q. Epub 2012 Mar 27. J Med Chem. 2012. PMID: 22420767

8

Multi-objective evolutionary design of adenosine receptor ligands.

van der Horst E, Marqués-Gallego P, Mulder-Krieger T, van Veldhoven J, Kruisselbrink J, Aleman A, Emmerich MT, Brussee J, Bender A, Ijzerman AP. van der Horst E, et al. J Chem Inf Model. 2012 Jul 23;52(7):1713-21. doi: 10.1021/ci2005115. Epub 2012 Jun 21. J Chem Inf Model. 2012. PMID: 22647079

9

Adenosine A₂B receptor agonism inhibits neointimal lesion development after arterial injury in apolipoprotein E-deficient mice.

Bot I, de Vries H, Korporaal SJ, Foks AC, Bot M, van Veldhoven J, Ter Borg MN, van Santbrink PJ, van Berkel TJ, Kuiper J, Ijzerman AP. Bot I, et al. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2197-205. doi: 10.1161/ATVBAHA.112.252924. Epub 2012 Jun 28. Arterioscler Thromb Vasc Biol. 2012. PMID: 22743060

10

Dual-point competition association assay: a fast and high-throughput kinetic screening method for assessing ligand-receptor binding kinetics.

Guo D, van Dorp EJ, Mulder-Krieger T, van Veldhoven JP, Brussee J, Ijzerman AP, Heitman LH. Guo D, et al. J Biomol Screen. 2013 Mar;18(3):309-20. doi: 10.1177/1087057112464776. Epub 2012 Oct 23. J Biomol Screen. 2013. PMID: 23093571

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