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LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.
Taraborrelli L, Peltzer N, Montinaro A, Kupka S, Rieser E, Hartwig T, Sarr A, Darding M, Draber P, Haas TL, Akarca A, Marafioti T, Pasparakis M, Bertin J, Gough PJ, Bouillet P, Strasser A, Leverkus M, Silke J, Walczak H. Taraborrelli L, et al. Among authors: pasparakis m. Nat Commun. 2018 Sep 25;9(1):3910. doi: 10.1038/s41467-018-06155-8. Nat Commun. 2018. PMID: 30254289 Free PMC article.
Epithelial NEMO links innate immunity to chronic intestinal inflammation.
Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M. Nenci A, et al. Among authors: pasparakis m. Nature. 2007 Mar 29;446(7135):557-61. doi: 10.1038/nature05698. Epub 2007 Mar 14. Nature. 2007. PMID: 17361131 Free article.
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I. Ikeda F, et al. Among authors: pasparakis m. Nature. 2011 Mar 31;471(7340):637-41. doi: 10.1038/nature09814. Nature. 2011. PMID: 21455181 Free PMC article.
Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout.
Ehlken H, Krishna-Subramanian S, Ochoa-Callejero L, Kondylis V, Nadi NE, Straub BK, Schirmacher P, Walczak H, Kollias G, Pasparakis M. Ehlken H, et al. Among authors: pasparakis m. Cell Death Differ. 2014 Nov;21(11):1721-32. doi: 10.1038/cdd.2014.83. Epub 2014 Jun 27. Cell Death Differ. 2014. PMID: 24971483 Free PMC article.
202 results