Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis.
Borsig L, Wong R, Hynes RO, Varki NM, Varki A.
Borsig L, et al. Among authors: varki a, varki nm.
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2193-8. doi: 10.1073/pnas.261704098.
Proc Natl Acad Sci U S A. 2002.
PMID: 11854515
Free PMC article.
P-selectin facilitates human carcinoma metastasis in immunodeficient mice by mediating early interactions of platelets with bloodborne tumor cells via their cell surface mucins, and this process can be blocked by heparin [Borsig, L., Wong, R., Feramisco, J., Nadeau, D. R., Var …
P-selectin facilitates human carcinoma metastasis in immunodeficient mice by mediating early interactions of platelets with bloodborne tumor …