Koike T - Search Results

1

Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors.

Aida J, Fushimi M, Kusumoto T, Sugiyama H, Arimura N, Ikeda S, Sasaki M, Sogabe S, Aoyama K, Koike T. Aida J, et al. Among authors: koike t. J Med Chem. 2018 Oct 25;61(20):9205-9217. doi: 10.1021/acs.jmedchem.8b00824. Epub 2018 Oct 10. J Med Chem. 2018. PMID: 30251836

2

1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT₂-selective agonists.

Koike T, Hoashi Y, Takai T, Nakayama M, Yukuhiro N, Ishikawa T, Hirai K, Uchikawa O. Koike T, et al. J Med Chem. 2011 May 12;54(9):3436-44. doi: 10.1021/jm200221q. Epub 2011 Apr 7. J Med Chem. 2011. PMID: 21473625

3

Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as melatonin receptor (MT1/MT2) ligands.

Koike T, Takai T, Hoashi Y, Nakayama M, Kosugi Y, Nakashima M, Yoshikubo S, Hirai K, Uchikawa O. Koike T, et al. J Med Chem. 2011 Jun 23;54(12):4207-18. doi: 10.1021/jm200385u. Epub 2011 May 24. J Med Chem. 2011. PMID: 21568291

4

Design and synthesis of piperazine derivatives as a novel class of γ-secretase modulators that selectively lower Aβ₄₂ production.

Takai T, Koike T, Honda E, Kajita Y, Nakamura M, Morimoto S, Hoashi Y, Kamata M, Watanabe T, Igari T, Terauchi J. Takai T, et al. Among authors: koike t. Bioorg Med Chem. 2015 May 1;23(9):1923-34. doi: 10.1016/j.bmc.2015.03.055. Epub 2015 Mar 28. Bioorg Med Chem. 2015. PMID: 25842363

5

Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators.

Takai T, Hoashi Y, Tomata Y, Morimoto S, Nakamura M, Watanabe T, Igari T, Koike T. Takai T, et al. Among authors: koike t. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4245-9. doi: 10.1016/j.bmcl.2015.07.101. Epub 2015 Aug 7. Bioorg Med Chem Lett. 2015. PMID: 26298496

6

Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2).

Takai T, Koike T, Nakamura M, Kajita Y, Yamashita T, Taya N, Tsukamoto T, Watanabe T, Murakami K, Igari T, Kamata M. Takai T, et al. Among authors: koike t. Bioorg Med Chem. 2016 Jul 15;24(14):3192-206. doi: 10.1016/j.bmc.2016.05.040. Epub 2016 May 20. Bioorg Med Chem. 2016. PMID: 27255179

7

Discovery of novel 4-phenyl-2-(pyrrolidinyl)nicotinamide derivatives as potent Na_v1.1 activators.

Miyazaki T, Kawasaki M, Suzuki A, Ito Y, Imanishi A, Maru T, Kawamoto T, Koike T. Miyazaki T, et al. Among authors: koike t. Bioorg Med Chem Lett. 2019 Mar 15;29(6):815-820. doi: 10.1016/j.bmcl.2019.01.023. Epub 2019 Jan 23. Bioorg Med Chem Lett. 2019. PMID: 30704812

8

Design, Synthesis, and Evaluation of (4 R)-1-{3-[2-(¹⁸F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([¹⁸F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase.

Hattori Y, Aoyama K, Maeda J, Arimura N, Takahashi Y, Sasaki M, Fujinaga M, Seki C, Nagai Y, Kawamura K, Yamasaki T, Zhang MR, Higuchi M, Koike T. Hattori Y, et al. Among authors: koike t. J Med Chem. 2019 Mar 14;62(5):2362-2375. doi: 10.1021/acs.jmedchem.8b01576. Epub 2019 Feb 26. J Med Chem. 2019. PMID: 30753069

9

Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization.

Tawada M, Fushimi M, Masuda K, Sun H, Uchiyama N, Kosugi Y, Lane W, Tjhen R, Endo S, Koike T. Tawada M, et al. Among authors: koike t. J Med Chem. 2021 Jan 28;64(2):1103-1115. doi: 10.1021/acs.jmedchem.0c01712. Epub 2021 Jan 6. J Med Chem. 2021. PMID: 33404239

10

Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.

Hoashi Y, Takai T, Kosugi Y, Nakashima M, Nakayama M, Hirai K, Uchikawa O, Koike T. Hoashi Y, et al. Among authors: koike t. J Med Chem. 2021 Mar 25;64(6):3059-3074. doi: 10.1021/acs.jmedchem.0c01836. Epub 2021 Mar 7. J Med Chem. 2021. PMID: 33682410

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