Mielech AM - Search Results

1

The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species.

Niemeyer D, Mösbauer K, Klein EM, Sieberg A, Mettelman RC, Mielech AM, Dijkman R, Baker SC, Drosten C, Müller MA. Niemeyer D, et al. Among authors: mielech am. PLoS Pathog. 2018 Sep 24;14(9):e1007296. doi: 10.1371/journal.ppat.1007296. eCollection 2018 Sep. PLoS Pathog. 2018. PMID: 30248143 Free PMC article.

2

Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors.

Kilianski A, Mielech AM, Deng X, Baker SC. Kilianski A, et al. Among authors: mielech am. J Virol. 2013 Nov;87(21):11955-62. doi: 10.1128/JVI.02105-13. Epub 2013 Aug 28. J Virol. 2013. PMID: 23986593 Free PMC article.

3

MERS-CoV papain-like protease has deISGylating and deubiquitinating activities.

Mielech AM, Kilianski A, Baez-Santos YM, Mesecar AD, Baker SC. Mielech AM, et al. Virology. 2014 Feb;450-451:64-70. doi: 10.1016/j.virol.2013.11.040. Epub 2013 Dec 22. Virology. 2014. PMID: 24503068 Free PMC article.

4

Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities.

Mielech AM, Chen Y, Mesecar AD, Baker SC. Mielech AM, et al. Virus Res. 2014 Dec 19;194:184-90. doi: 10.1016/j.virusres.2014.01.025. Epub 2014 Feb 7. Virus Res. 2014. PMID: 24512893 Free PMC article. Review.

5

Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.

Mielech AM, Deng X, Chen Y, Kindler E, Wheeler DL, Mesecar AD, Thiel V, Perlman S, Baker SC. Mielech AM, et al. J Virol. 2015 May;89(9):4907-17. doi: 10.1128/JVI.00338-15. Epub 2015 Feb 18. J Virol. 2015. PMID: 25694594 Free PMC article.

6

Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages.

Deng X, Hackbart M, Mettelman RC, O'Brien A, Mielech AM, Yi G, Kao CC, Baker SC. Deng X, et al. Among authors: mielech am. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4251-E4260. doi: 10.1073/pnas.1618310114. Epub 2017 May 8. Proc Natl Acad Sci U S A. 2017. PMID: 28484023 Free PMC article.

7

Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.

Deng X, Chen Y, Mielech AM, Hackbart M, Kesely KR, Mettelman RC, O'Brien A, Chapman ME, Mesecar AD, Baker SC. Deng X, et al. Among authors: mielech am. J Virol. 2020 May 18;94(11):e01734-19. doi: 10.1128/JVI.01734-19. Print 2020 May 18. J Virol. 2020. PMID: 32188728 Free PMC article.

8

Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.

Báez-Santos YM, Mielech AM, Deng X, Baker S, Mesecar AD. Báez-Santos YM, et al. Among authors: mielech am. J Virol. 2014 Nov;88(21):12511-27. doi: 10.1128/JVI.01294-14. Epub 2014 Aug 20. J Virol. 2014. PMID: 25142582 Free PMC article.

9

X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases.

Báez-Santos YM, Barraza SJ, Wilson MW, Agius MP, Mielech AM, Davis NM, Baker SC, Larsen SD, Mesecar AD. Báez-Santos YM, et al. Among authors: mielech am. J Med Chem. 2014 Mar 27;57(6):2393-412. doi: 10.1021/jm401712t. Epub 2014 Mar 14. J Med Chem. 2014. PMID: 24568342 Free PMC article.

10

A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.

Deng X, Agnihothram S, Mielech AM, Nichols DB, Wilson MW, StJohn SE, Larsen SD, Mesecar AD, Lenschow DJ, Baric RS, Baker SC. Deng X, et al. Among authors: mielech am. J Virol. 2014 Oct;88(20):11825-33. doi: 10.1128/JVI.01749-14. Epub 2014 Aug 6. J Virol. 2014. PMID: 25100850 Free PMC article.

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