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Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability.
Välimäki N, Kuisma H, Pasanen A, Heikinheimo O, Sjöberg J, Bützow R, Sarvilinna N, Heinonen HR, Tolvanen J, Bramante S, Tanskanen T, Auvinen J, Uimari O, Alkodsi A, Lehtonen R, Kaasinen E, Palin K, Aaltonen LA. Välimäki N, et al. Among authors: uimari o. Elife. 2018 Sep 18;7:e37110. doi: 10.7554/eLife.37110. Elife. 2018. PMID: 30226466 Free PMC article.
MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas.
Kämpjärvi K, Mäkinen N, Mehine M, Välipakka S, Uimari O, Pitkänen E, Heinonen HR, Heikkinen T, Tolvanen J, Ahtikoski A, Frizzell N, Sarvilinna N, Sjöberg J, Bützow R, Aaltonen LA, Vahteristo P. Kämpjärvi K, et al. Among authors: uimari o. Br J Cancer. 2016 Jun 14;114(12):1405-11. doi: 10.1038/bjc.2016.130. Epub 2016 May 17. Br J Cancer. 2016. PMID: 27187686 Free PMC article.
Uterine fibroids and cardiovascular risk.
Uimari O, Auvinen J, Jokelainen J, Puukka K, Ruokonen A, Järvelin MR, Piltonen T, Keinänen-Kiukaanniemi S, Zondervan K, Järvelä I, Ryynänen M, Martikainen H. Uimari O, et al. Hum Reprod. 2016 Dec;31(12):2689-2703. doi: 10.1093/humrep/dew249. Epub 2016 Oct 12. Hum Reprod. 2016. PMID: 27733532 Free article.
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
Gallagher CS, Mäkinen N, Harris HR, Rahmioglu N, Uimari O, Cook JP, Shigesi N, Ferreira T, Velez-Edwards DR, Edwards TL, Mortlock S, Ruhioglu Z, Day F, Becker CM, Karhunen V, Martikainen H, Järvelin MR, Cantor RM, Ridker PM, Terry KL, Buring JE, Gordon SD, Medland SE, Montgomery GW, Nyholt DR, Hinds DA, Tung JY; 23andMe Research Team; Perry JRB, Lind PA, Painter JN, Martin NG, Morris AP, Chasman DI, Missmer SA, Zondervan KT, Morton CC. Gallagher CS, et al. Among authors: uimari o. Nat Commun. 2019 Oct 24;10(1):4857. doi: 10.1038/s41467-019-12536-4. Nat Commun. 2019. PMID: 31649266 Free PMC article.
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection.
Zekavat SM, Lin SH, Bick AG, Liu A, Paruchuri K, Wang C, Uddin MM, Ye Y, Yu Z, Liu X, Kamatani Y, Bhattacharya R, Pirruccello JP, Pampana A, Loh PR, Kohli P, McCarroll SA, Kiryluk K, Neale B, Ionita-Laza I, Engels EA, Brown DW, Smoller JW, Green R, Karlson EW, Lebo M, Ellinor PT, Weiss ST, Daly MJ; Biobank Japan Project; FinnGen Consortium; Terao C, Zhao H, Ebert BL, Reilly MP, Ganna A, Machiela MJ, Genovese G, Natarajan P. Zekavat SM, et al. Nat Med. 2021 Jun;27(6):1012-1024. doi: 10.1038/s41591-021-01371-0. Epub 2021 Jun 7. Nat Med. 2021. PMID: 34099924 Free PMC article.
Uterine leiomyomas in hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome can be identified through distinct clinical characteristics and typical morphology.
Uimari O, Ahtikoski A, Kämpjärvi K, Butzow R, Järvelä IY, Ryynänen M, Aaltonen LA, Vahteristo P, Kuismin O. Uimari O, et al. Acta Obstet Gynecol Scand. 2021 Nov;100(11):2066-2075. doi: 10.1111/aogs.14248. Epub 2021 Sep 3. Acta Obstet Gynecol Scand. 2021. PMID: 34480341 Free article.
44 results