Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice.
Liangpunsakul S, Rahmini Y, Ross RA, Zhao Z, Xu Y, Crabb DW.
Liangpunsakul S, et al.
Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G515-23. doi: 10.1152/ajpgi.00455.2011. Epub 2011 Dec 22.
Am J Physiol Gastrointest Liver Physiol. 2012.
PMID: 22194417
Free PMC article.
Our previous data showed the inhibitory effect of ethanol on AMP-activated protein kinase phosphorylation, which appears to be mediated, in part, through increased levels of hepatic ceramide and activation of protein phosphatase 2A (Liangpunsakul S, Sozio MS, Shin E …
Our previous data showed the inhibitory effect of ethanol on AMP-activated protein kinase phosphorylation, which appears to be mediated, in …