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Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation.
Luijk R, Wu H, Ward-Caviness CK, Hannon E, Carnero-Montoro E, Min JL, Mandaviya P, Müller-Nurasyid M, Mei H, van der Maarel SM; BIOS Consortium; Relton C, Mill J, Waldenberger M, Bell JT, Jansen R, Zhernakova A, Franke L, 't Hoen PAC, Boomsma DI, van Duijn CM, van Greevenbroek MMJ, Veldink JH, Wijmenga C, van Meurs J, Daxinger L, Slagboom PE, van Zwet EW, Heijmans BT. Luijk R, et al. Among authors: daxinger l. Nat Commun. 2018 Sep 14;9(1):3738. doi: 10.1038/s41467-018-05714-3. Nat Commun. 2018. PMID: 30218040 Free PMC article.
An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation.
Gao Z, Liu HL, Daxinger L, Pontes O, He X, Qian W, Lin H, Xie M, Lorkovic ZJ, Zhang S, Miki D, Zhan X, Pontier D, Lagrange T, Jin H, Matzke AJ, Matzke M, Pikaard CS, Zhu JK. Gao Z, et al. Among authors: daxinger l. Nature. 2010 May 6;465(7294):106-9. doi: 10.1038/nature09025. Epub 2010 Apr 21. Nature. 2010. PMID: 20410883 Free PMC article.
Genetic and epigenetic contributors to FSHD.
Daxinger L, Tapscott SJ, van der Maarel SM. Daxinger L, et al. Curr Opin Genet Dev. 2015 Aug;33:56-61. doi: 10.1016/j.gde.2015.08.007. Epub 2015 Sep 7. Curr Opin Genet Dev. 2015. PMID: 26356006 Free PMC article. Review.
Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference.
Hop PJ, Luijk R, Daxinger L, van Iterson M, Dekkers KF, Jansen R; BIOS Consortium; van Meurs JBJ, 't Hoen PAC, Ikram MA, van Greevenbroek MMJ, Boomsma DI, Slagboom PE, Veldink JH, van Zwet EW, Heijmans BT. Hop PJ, et al. Among authors: daxinger l. Genome Biol. 2020 Aug 28;21(1):220. doi: 10.1186/s13059-020-02114-z. Genome Biol. 2020. PMID: 32859263 Free PMC article.
A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair.
van den Heuvel D, Spruijt CG, González-Prieto R, Kragten A, Paulsen MT, Zhou D, Wu H, Apelt K, van der Weegen Y, Yang K, Dijk M, Daxinger L, Marteijn JA, Vertegaal ACO, Ljungman M, Vermeulen M, Luijsterburg MS. van den Heuvel D, et al. Among authors: daxinger l. Nat Commun. 2021 Feb 26;12(1):1342. doi: 10.1038/s41467-021-21520-w. Nat Commun. 2021. PMID: 33637760 Free PMC article.
Identical twins carry a persistent epigenetic signature of early genome programming.
van Dongen J, Gordon SD, McRae AF, Odintsova VV, Mbarek H, Breeze CE, Sugden K, Lundgren S, Castillo-Fernandez JE, Hannon E, Moffitt TE, Hagenbeek FA, van Beijsterveldt CEM, Jan Hottenga J, Tsai PC; BIOS Consortium; Genetics of DNA Methylation Consortium; Min JL, Hemani G, Ehli EA, Paul F, Stern CD, Heijmans BT, Slagboom PE, Daxinger L, van der Maarel SM, de Geus EJC, Willemsen G, Montgomery GW, Reversade B, Ollikainen M, Kaprio J, Spector TD, Bell JT, Mill J, Caspi A, Martin NG, Boomsma DI. van Dongen J, et al. Among authors: daxinger l. Nat Commun. 2021 Sep 28;12(1):5618. doi: 10.1038/s41467-021-25583-7. Nat Commun. 2021. PMID: 34584077 Free PMC article.
SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease.
Tapia Del Fierro A, den Hamer B, Benetti N, Jansz N, Chen K, Beck T, Vanyai H, Gurzau AD, Daxinger L, Xue S, Ly TTN, Wanigasuriya I, Iminitoff M, Breslin K, Oey H, Krom YD, van der Hoorn D, Bouwman LF, Johanson TM, Ritchie ME, Gouil QA, Reversade B, Prin F, Mohun T, van der Maarel SM, McGlinn E, Murphy JM, Keniry A, de Greef JC, Blewitt ME. Tapia Del Fierro A, et al. Among authors: daxinger l. Nat Commun. 2023 Sep 25;14(1):5466. doi: 10.1038/s41467-023-40992-6. Nat Commun. 2023. PMID: 37749075 Free PMC article.
51 results