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Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity.
Wang S, Klein SO, Urban S, Staudt M, Barthes NPF, Willmann D, Bacher J, Sum M, Bauer H, Peng L, Rennar GA, Gratzke C, Schüle KM, Zhang L, Einsle O, Greschik H, MacLeod C, Thomson CG, Jung M, Metzger E, Schüle R. Wang S, et al. Among authors: rennar ga. Nat Commun. 2024 Jan 2;15(1):43. doi: 10.1038/s41467-023-44243-6. Nat Commun. 2024. PMID: 38167811 Free PMC article.
Identification and characterisation of the tegument-expressed aldehyde dehydrogenase SmALDH_312 of Schistosoma mansoni, a target of disulfiram.
Beutler M, Harnischfeger J, Weber MHW, Hahnel SR, Quack T, Blohm A, Ueberall ME, Timm T, Lochnit G, Rennar GA, Gallinger TL, Houhou H, Rahlfs S, Falcone FH, Becker K, Schlitzer M, Haeberlein S, Czermak P, Salzig D, Grevelding CG. Beutler M, et al. Among authors: rennar ga. Eur J Med Chem. 2023 May 5;251:115179. doi: 10.1016/j.ejmech.2023.115179. Epub 2023 Feb 10. Eur J Med Chem. 2023. PMID: 36948075 Free article.