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Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I.
Dezfulian C, Shiva S, Alekseyenko A, Pendyal A, Beiser DG, Munasinghe JP, Anderson SA, Chesley CF, Vanden Hoek TL, Gladwin MT. Dezfulian C, et al. Circulation. 2009 Sep 8;120(10):897-905. doi: 10.1161/CIRCULATIONAHA.109.853267. Epub 2009 Aug 24. Circulation. 2009. PMID: 19704094 Free PMC article.
Nitrite therapy is neuroprotective and safe in cardiac arrest survivors.
Dezfulian C, Alekseyenko A, Dave KR, Raval AP, Do R, Kim F, Perez-Pinzon MA. Dezfulian C, et al. Nitric Oxide. 2012 May 15;26(4):241-50. doi: 10.1016/j.niox.2012.03.007. Epub 2012 Mar 30. Nitric Oxide. 2012. PMID: 22484664 Free PMC article. Clinical Trial.
The association between hyperoxia and patient outcomes after cardiac arrest: analysis of a high-resolution database.
Elmer J, Scutella M, Pullalarevu R, Wang B, Vaghasia N, Trzeciak S, Rosario-Rivera BL, Guyette FX, Rittenberger JC, Dezfulian C; Pittsburgh Post-Cardiac Arrest Service (PCAS). Elmer J, et al. Among authors: dezfulian c. Intensive Care Med. 2015 Jan;41(1):49-57. doi: 10.1007/s00134-014-3555-6. Epub 2014 Dec 4. Intensive Care Med. 2015. PMID: 25472570 Free PMC article.
Validation of the Pittsburgh Cardiac Arrest Category illness severity score.
Coppler PJ, Elmer J, Calderon L, Sabedra A, Doshi AA, Callaway CW, Rittenberger JC, Dezfulian C; Post Cardiac Arrest Service. Coppler PJ, et al. Among authors: dezfulian c. Resuscitation. 2015 Apr;89:86-92. doi: 10.1016/j.resuscitation.2015.01.020. Epub 2015 Jan 28. Resuscitation. 2015. PMID: 25636896 Free PMC article.
Neurocognitive outcomes following successful resuscitation from cardiac arrest.
Sabedra AR, Kristan J, Raina K, Holm MB, Callaway CW, Guyette FX, Dezfulian C, Doshi AA, Rittenberger JC; Post Cardiac Arrest Service. Sabedra AR, et al. Among authors: dezfulian c. Resuscitation. 2015 May;90:67-72. doi: 10.1016/j.resuscitation.2015.02.023. Epub 2015 Feb 28. Resuscitation. 2015. PMID: 25737082 Free PMC article.
107 results