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( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.
Liu Y, Ji L, Eno M, Kudalkar S, Li AL, Schimpgen M, Benchama O, Morales P, Xu S, Hurst D, Wu S, Mohammad KA, Wood JT, Zvonok N, Papahatjis DP, Zhou H, Honrao C, Mackie K, Reggio P, Hohmann AG, Marnett LJ, Makriyannis A, Nikas SP. Liu Y, et al. Among authors: papahatjis dp. J Med Chem. 2018 Oct 11;61(19):8639-8657. doi: 10.1021/acs.jmedchem.8b00611. Epub 2018 Sep 21. J Med Chem. 2018. PMID: 30196704
The application of 3D-QSAR studies for novel cannabinoid ligands substituted at the C1' position of the alkyl side chain on the structural requirements for binding to cannabinoid receptors CB1 and CB2.
Durdagi S, Kapou A, Kourouli T, Andreou T, Nikas SP, Nahmias VR, Papahatjis DP, Papadopoulos MG, Mavromoustakos T. Durdagi S, et al. Among authors: papahatjis dp. J Med Chem. 2007 Jun 14;50(12):2875-85. doi: 10.1021/jm0610705. Epub 2007 May 24. J Med Chem. 2007. PMID: 17521177
C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols.
Papahatjis DP, Nahmias VR, Nikas SP, Andreou T, Alapafuja SO, Tsotinis A, Guo J, Fan P, Makriyannis A. Papahatjis DP, et al. J Med Chem. 2007 Aug 23;50(17):4048-60. doi: 10.1021/jm070121a. Epub 2007 Aug 2. J Med Chem. 2007. PMID: 17672444
Novel 1',1'-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist.
Nikas SP, Alapafuja SO, Papanastasiou I, Paronis CA, Shukla VG, Papahatjis DP, Bowman AL, Halikhedkar A, Han X, Makriyannis A. Nikas SP, et al. Among authors: papahatjis dp. J Med Chem. 2010 Oct 14;53(19):6996-7010. doi: 10.1021/jm100641g. J Med Chem. 2010. PMID: 20925434 Free PMC article.
22 results