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( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.
Liu Y, Ji L, Eno M, Kudalkar S, Li AL, Schimpgen M, Benchama O, Morales P, Xu S, Hurst D, Wu S, Mohammad KA, Wood JT, Zvonok N, Papahatjis DP, Zhou H, Honrao C, Mackie K, Reggio P, Hohmann AG, Marnett LJ, Makriyannis A, Nikas SP. Liu Y, et al. Among authors: nikas sp. J Med Chem. 2018 Oct 11;61(19):8639-8657. doi: 10.1021/acs.jmedchem.8b00611. Epub 2018 Sep 21. J Med Chem. 2018. PMID: 30196704
Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols.
Papahatjis DP, Nikas SP, Andreou T, Makriyannis A. Papahatjis DP, et al. Among authors: nikas sp. Bioorg Med Chem Lett. 2002 Dec 16;12(24):3583-6. doi: 10.1016/s0960-894x(02)00785-0. Bioorg Med Chem Lett. 2002. PMID: 12443781
CB1 cannabinoid receptor ligands.
Thakur GA, Nikas SP, Makriyannis A. Thakur GA, et al. Among authors: nikas sp. Mini Rev Med Chem. 2005 Jul;5(7):631-40. doi: 10.2174/1389557054368772. Mini Rev Med Chem. 2005. PMID: 16026309 Review.
Methods for the synthesis of cannabinergic ligands.
Thakur GA, Nikas SP, Duclos RI Jr, Makriyannis A. Thakur GA, et al. Among authors: nikas sp. Methods Mol Med. 2006;123:113-48. doi: 10.1385/1-59259-999-0:113. Methods Mol Med. 2006. PMID: 16506405
Cannabinoid receptors as therapeutic targets.
Pavlopoulos S, Thakur GA, Nikas SP, Makriyannis A. Pavlopoulos S, et al. Among authors: nikas sp. Curr Pharm Des. 2006;12(14):1751-69. doi: 10.2174/138161206776873743. Curr Pharm Des. 2006. PMID: 16712486 Review.
The application of 3D-QSAR studies for novel cannabinoid ligands substituted at the C1' position of the alkyl side chain on the structural requirements for binding to cannabinoid receptors CB1 and CB2.
Durdagi S, Kapou A, Kourouli T, Andreou T, Nikas SP, Nahmias VR, Papahatjis DP, Papadopoulos MG, Mavromoustakos T. Durdagi S, et al. Among authors: nikas sp. J Med Chem. 2007 Jun 14;50(12):2875-85. doi: 10.1021/jm0610705. Epub 2007 May 24. J Med Chem. 2007. PMID: 17521177
74 results