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( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.
Liu Y, Ji L, Eno M, Kudalkar S, Li AL, Schimpgen M, Benchama O, Morales P, Xu S, Hurst D, Wu S, Mohammad KA, Wood JT, Zvonok N, Papahatjis DP, Zhou H, Honrao C, Mackie K, Reggio P, Hohmann AG, Marnett LJ, Makriyannis A, Nikas SP. Liu Y, et al. Among authors: ji l. J Med Chem. 2018 Oct 11;61(19):8639-8657. doi: 10.1021/acs.jmedchem.8b00611. Epub 2018 Sep 21. J Med Chem. 2018. PMID: 30196704
Antiemetic Effects of Cannabinoid Agonists in Nonhuman Primates.
Wooldridge LM, Ji L, Liu Y, Nikas SP, Makriyannis A, Bergman J, Kangas BD. Wooldridge LM, et al. Among authors: ji l. J Pharmacol Exp Ther. 2020 Sep;374(3):462-468. doi: 10.1124/jpet.120.265710. Epub 2020 Jun 19. J Pharmacol Exp Ther. 2020. PMID: 32561684 Free PMC article.
Cannabinoid-2 Agonism with AM2301 Mitigates Morphine-Induced Respiratory Depression.
Wiese BM, Liktor-Busa E, Levine A, Couture SA, Nikas SP, Ji L, Liu Y, Mackie K, Makriyannis A, Largent-Milnes TM, Vanderah TW. Wiese BM, et al. Among authors: ji l. Cannabis Cannabinoid Res. 2021 Oct;6(5):401-412. doi: 10.1089/can.2020.0076. Epub 2020 Nov 13. Cannabis Cannabinoid Res. 2021. PMID: 33998869 Free PMC article.
Brain Penetrant, but not Peripherally Restricted, Synthetic Cannabinoid 1 Receptor Agonists Promote Morphine-Mediated Respiratory Depression.
Wiese BM, Liktor-Busa E, Couture SA, Nikas SP, Ji L, Liu Y, Makriyannis A, Spigelman I, Vanderah TW, Largent-Milnes TM. Wiese BM, et al. Among authors: ji l. Cannabis Cannabinoid Res. 2022 Oct;7(5):621-627. doi: 10.1089/can.2021.0090. Epub 2021 Dec 17. Cannabis Cannabinoid Res. 2022. PMID: 34935460 Free PMC article.
Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists.
Papanastasiou IP, Georgiadis MO, Iliopoulos-Tsoutsouvas C, Paronis CA, Brust CA, Tran NK, Ji L, Ma X, Wood JT, Zvonok N, Tong F, Bohn LM, Nikas SP, Makriyannis A. Papanastasiou IP, et al. Among authors: ji l. Eur J Med Chem. 2022 Feb 15;230:114027. doi: 10.1016/j.ejmech.2021.114027. Epub 2021 Dec 27. Eur J Med Chem. 2022. PMID: 35051750
Structural basis for activation of CB1 by an endocannabinoid analog.
Krishna Kumar K, Robertson MJ, Thadhani E, Wang H, Suomivuori CM, Powers AS, Ji L, Nikas SP, Dror RO, Inoue A, Makriyannis A, Skiniotis G, Kobilka B. Krishna Kumar K, et al. Among authors: ji l. Nat Commun. 2023 May 9;14(1):2672. doi: 10.1038/s41467-023-37864-4. Nat Commun. 2023. PMID: 37160876 Free PMC article.
5,391 results