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Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations.
Otten C, Knox J, Boulday G, Eymery M, Haniszewski M, Neuenschwander M, Radetzki S, Vogt I, Hähn K, De Luca C, Cardoso C, Hamad S, Igual Gil C, Roy P, Albiges-Rizo C, Faurobert E, von Kries JP, Campillos M, Tournier-Lasserve E, Derry WB, Abdelilah-Seyfried S. Otten C, et al. Among authors: von kries jp. EMBO Mol Med. 2018 Oct;10(10):e9155. doi: 10.15252/emmm.201809155. EMBO Mol Med. 2018. PMID: 30181117 Free PMC article.
Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition.
Kücükdisli M, Bel-Abed H, Cirillo D, Lo WT, Efrém NL, Horatscheck A, Perepelittchenko L, Prokofeva P, Ehret TAL, Radetzki S, Neuenschwander M, Specker E, Médard G, Müller S, Wilhelm S, Kuster B, von Kries JP, Haucke V, Nazaré M. Kücükdisli M, et al. Among authors: von kries jp. J Med Chem. 2023 Oct 26;66(20):14278-14302. doi: 10.1021/acs.jmedchem.3c01319. Epub 2023 Oct 11. J Med Chem. 2023. PMID: 37819647 Free PMC article.
Small Molecules Targeting Human N-Acetylmannosamine Kinase.
Hinderlich S, Neuenschwander M, Wratil PR, Oder A, Lisurek M, Nguyen LD, von Kries JP, Hackenberger CPR. Hinderlich S, et al. Among authors: von kries jp. Chembiochem. 2017 Jul 4;18(13):1279-1285. doi: 10.1002/cbic.201700066. Epub 2017 Apr 27. Chembiochem. 2017. PMID: 28346741
Loss-of-function uORF mutations in human malignancies.
Schulz J, Mah N, Neuenschwander M, Kischka T, Ratei R, Schlag PM, Castaños-Vélez E, Fichtner I, Tunn PU, Denkert C, Klaas O, Berdel WE, von Kries JP, Makalowski W, Andrade-Navarro MA, Leutz A, Wethmar K. Schulz J, et al. Among authors: von kries jp. Sci Rep. 2018 Feb 5;8(1):2395. doi: 10.1038/s41598-018-19201-8. Sci Rep. 2018. PMID: 29402903 Free PMC article.
High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs.
Merkert S, Schubert M, Olmer R, Engels L, Radetzki S, Veltman M, Scholte BJ, Zöllner J, Pedemonte N, Galietta LJV, von Kries JP, Martin U. Merkert S, et al. Among authors: von kries jp. Stem Cell Reports. 2019 Jun 11;12(6):1389-1403. doi: 10.1016/j.stemcr.2019.04.014. Epub 2019 May 9. Stem Cell Reports. 2019. PMID: 31080112 Free PMC article.
Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation.
Jordan P, Costa A, Specker E, Popp O, Volkamer A, Piske R, Obrusnik T, Kleissle S, Stuke K, Rex A, Neuenschwander M, von Kries JP, Nazare M, Mertins P, Kettenmann H, Wolf SA. Jordan P, et al. Among authors: von kries jp. PLoS One. 2023 Feb 6;18(2):e0278325. doi: 10.1371/journal.pone.0278325. eCollection 2023. PLoS One. 2023. PMID: 36745631 Free PMC article.
86 results