Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs.
Yang Y, Wu H, Kang X, Liang Y, Lan T, Li T, Tan T, Peng J, Zhang Q, An G, Liu Y, Yu Q, Ma Z, Lian Y, Soh BS, Chen Q, Liu P, Chen Y, Sun X, Li R, Zhen X, Liu P, Yu Y, Li X, Fan Y.
Yang Y, et al. Among authors: an g.
Protein Cell. 2018 Mar;9(3):283-297. doi: 10.1007/s13238-017-0499-y. Epub 2018 Jan 9.
Protein Cell. 2018.
PMID: 29318513
Free PMC article.
Mitochondria-targeted endonucleases provide an alternative avenue for treating mitochondrial disorders via targeted destruction of the mutant mtDNA and induction of heteroplasmic shifting. ...We engineered mitochondrial-targeted transcription activator-like effector nuclea …
Mitochondria-targeted endonucleases provide an alternative avenue for treating mitochondrial disorders via targeted destruction of th …