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Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism.
Ždralević M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, Peter K, Schnell A, Bruss C, Decking SM, Koehl G, Felipe-Abrio B, Durivault J, Bayer P, Evangelista M, O'Brien T, Oefner PJ, Renner K, Pouysségur J, Kreutz M. Ždralević M, et al. Among authors: brand a. J Biol Chem. 2018 Oct 12;293(41):15947-15961. doi: 10.1074/jbc.RA118.004180. Epub 2018 Aug 29. J Biol Chem. 2018. PMID: 30158244 Free PMC article.
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner PJ, Hoffmann P, Walenta S, Geissler EK, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M. Brand A, et al. Cell Metab. 2016 Nov 8;24(5):657-671. doi: 10.1016/j.cmet.2016.08.011. Epub 2016 Sep 15. Cell Metab. 2016. PMID: 27641098 Free article.
Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages.
Bohn T, Rapp S, Luther N, Klein M, Bruehl TJ, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst HC, von Stebut E, Becker C, Schild H, Schmitt E, Bopp T. Bohn T, et al. Among authors: brand a. Nat Immunol. 2018 Dec;19(12):1319-1329. doi: 10.1038/s41590-018-0226-8. Epub 2018 Nov 5. Nat Immunol. 2018. PMID: 30397348
The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients.
Spanier G, Ugele I, Nieberle F, Symeou L, Schmidhofer S, Brand A, Meier J, Spoerl S, Krupar R, Rümmele P, Siska P, Renner K, Peter K, Gerken M, Beckhove P, Reichert TE, Kreutz M, Singer K. Spanier G, et al. Among authors: brand a. Cancer Lett. 2021 Feb 28;499:209-219. doi: 10.1016/j.canlet.2020.11.029. Epub 2020 Dec 1. Cancer Lett. 2021. PMID: 33276040 Free article.
Sex-Dependent T Cell Dysregulation in Mice with Diet-Induced Obesity.
Brummer C, Singer K, Brand A, Bruss C, Renner K, Herr W, Pukrop T, Dorn C, Hellerbrand C, Matos C, Kreutz M. Brummer C, et al. Among authors: brand a. Int J Mol Sci. 2024 Jul 28;25(15):8234. doi: 10.3390/ijms25158234. Int J Mol Sci. 2024. PMID: 39125804 Free PMC article.
1,363 results