Frydman J - Search Results

1

Huntingtin's N-Terminus Rearrangements in the Presence of Membranes: A Joint Spectroscopic and Computational Perspective.

Levy GR, Shen K, Gavrilov Y, Smith PES, Levy Y, Chan R, Frydman J, Frydman L. Levy GR, et al. Among authors: frydman l, frydman j. ACS Chem Neurosci. 2019 Jan 16;10(1):472-481. doi: 10.1021/acschemneuro.8b00353. Epub 2018 Sep 17. ACS Chem Neurosci. 2019. PMID: 30149694

2

The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntingtin aggregation.

Kelley NW, Huang X, Tam S, Spiess C, Frydman J, Pande VS. Kelley NW, et al. Among authors: frydman j. J Mol Biol. 2009 May 22;388(5):919-27. doi: 10.1016/j.jmb.2009.01.032. Epub 2009 Jan 23. J Mol Biol. 2009. PMID: 19361448 Free PMC article.

3

TRiC's tricks inhibit huntingtin aggregation.

Shahmoradian SH, Galaz-Montoya JG, Schmid MF, Cong Y, Ma B, Spiess C, Frydman J, Ludtke SJ, Chiu W. Shahmoradian SH, et al. Among authors: frydman j. Elife. 2013 Jul 9;2:e00710. doi: 10.7554/eLife.00710. Elife. 2013. PMID: 23853712 Free PMC article.

4

Super-resolution fluorescence of huntingtin reveals growth of globular species into short fibers and coexistence of distinct aggregates.

Duim WC, Jiang Y, Shen K, Frydman J, Moerner WE. Duim WC, et al. Among authors: frydman j. ACS Chem Biol. 2014 Dec 19;9(12):2767-78. doi: 10.1021/cb500335w. Epub 2014 Oct 20. ACS Chem Biol. 2014. PMID: 25330023 Free PMC article.

5

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.

Shen K, Calamini B, Fauerbach JA, Ma B, Shahmoradian SH, Serrano Lachapel IL, Chiu W, Lo DC, Frydman J. Shen K, et al. Among authors: frydman j. Elife. 2016 Oct 18;5:e18065. doi: 10.7554/eLife.18065. Elife. 2016. PMID: 27751235 Free PMC article.

6

Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective.

Baias M, Smith PE, Shen K, Joachimiak LA, Żerko S, Koźmiński W, Frydman J, Frydman L. Baias M, et al. Among authors: frydman l, frydman j. J Am Chem Soc. 2017 Jan 25;139(3):1168-1176. doi: 10.1021/jacs.6b10893. Epub 2017 Jan 13. J Am Chem Soc. 2017. PMID: 28085263

7

Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies.

Shen K, Gamerdinger M, Chan R, Gense K, Martin EM, Sachs N, Knight PD, Schlömer R, Calabrese AN, Stewart KL, Leiendecker L, Baghel A, Radford SE, Frydman J, Deuerling E. Shen K, et al. Among authors: frydman j. Mol Cell. 2019 May 16;74(4):729-741.e7. doi: 10.1016/j.molcel.2019.03.012. Epub 2019 Apr 11. Mol Cell. 2019. PMID: 30982745 Free PMC article.

8

Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington's disease patients.

Lee CYD, Wang N, Shen K, Stricos M, Langfelder P, Cheon KH, Cortés EP, Vinters HV, Vonsattel JP, Wexler NS, Damoiseaux R, Frydman J, Yang XW. Lee CYD, et al. Among authors: frydman j. Sci Rep. 2020 Nov 20;10(1):20295. doi: 10.1038/s41598-020-77164-1. Sci Rep. 2020. PMID: 33219289 Free PMC article.

9

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates.

Galaz-Montoya JG, Shahmoradian SH, Shen K, Frydman J, Chiu W. Galaz-Montoya JG, et al. Among authors: frydman j. Commun Biol. 2021 Jul 8;4(1):849. doi: 10.1038/s42003-021-02360-2. Commun Biol. 2021. PMID: 34239038 Free PMC article.

10

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions.

Tam S, Geller R, Spiess C, Frydman J. Tam S, et al. Among authors: frydman j. Nat Cell Biol. 2006 Oct;8(10):1155-62. doi: 10.1038/ncb1477. Epub 2006 Sep 17. Nat Cell Biol. 2006. PMID: 16980959 Free PMC article.

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