Kessler H - Search Results

1

Orally Active Peptides: Is There a Magic Bullet?

Räder AFB, Weinmüller M, Reichart F, Schumacher-Klinger A, Merzbach S, Gilon C, Hoffman A, Kessler H. Räder AFB, et al. Among authors: kessler h. Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14414-14438. doi: 10.1002/anie.201807298. Epub 2018 Oct 3. Angew Chem Int Ed Engl. 2018. PMID: 30144240 Review.

2

Comparison of the conformation of active and nonactive backbone cyclic analogs of substance P as a tool to elucidate features of the bioactive conformation: NMR and molecular dynamics in DMSO and water.

Grdadolnik SG, Mierke DF, Byk G, Zeltser I, Gilon C, Kessler H. Grdadolnik SG, et al. Among authors: kessler h. J Med Chem. 1994 Jul 8;37(14):2145-52. doi: 10.1021/jm00040a005. J Med Chem. 1994. PMID: 7518522

3

Structure-activity relationship of the ring portion in backbone-cyclic C-terminal hexapeptide analogs of substance P. NMR and molecular dynamics.

Behrens S, Mathä B, Bitan G, Gilon C, Kessler H. Behrens S, et al. Among authors: kessler h. Int J Pept Protein Res. 1996 Dec;48(6):569-79. doi: 10.1111/j.1399-3011.1996.tb00876.x. Int J Pept Protein Res. 1996. PMID: 8985790

4

A backbone-cyclic, receptor 5-selective somatostatin analogue: synthesis, bioactivity, and nuclear magnetic resonance conformational analysis.

Gilon C, Huenges M, Mathä B, Gellerman G, Hornik V, Afargan M, Amitay O, Ziv O, Feller E, Gamliel A, Shohat D, Wanger M, Arad O, Kessler H. Gilon C, et al. Among authors: kessler h. J Med Chem. 1998 Mar 12;41(6):919-29. doi: 10.1021/jm970633x. J Med Chem. 1998. PMID: 9526566

5

Carbohydrate Derivatives for Use in Drug Design: Cyclic alpha(v)-Selective RGD Peptides This work was supported by the Fonds der Chemischen Industrie, the Deutsche Forschungsgemeinschaft, and the Sanderstiftung. The authors thank M. Urzinger, B. Cordes, M. Kranawetter, M. Wolff, and A. Zeller for technical assistance.

Lohof E, Planker E, Mang C, Burkhart F, Dechantsreiter MA, Haubner R, Wester HJ, Schwaiger M, Hölzemann G, Goodman SL, Kessler H. Lohof E, et al. Among authors: kessler h. Angew Chem Int Ed Engl. 2000 Aug 4;39(15):2761-2764. doi: 10.1002/1521-3773(20000804)39:15<2761::aid-anie2761>3.0.co;2-9. Angew Chem Int Ed Engl. 2000. PMID: 10934419 No abstract available.

6

Combinatorial and rational strategies to develop nonpeptidic alpha4beta7-integrin antagonists from cyclic peptides.

Gottschling D, Boer J, Schuster A, Holzmann B, Kessler H. Gottschling D, et al. Among authors: kessler h. Angew Chem Int Ed Engl. 2002 Aug 16;41(16):3007-11. doi: 10.1002/1521-3773(20020816)41:16<3007::AID-ANIE3007>3.0.CO;2-3. Angew Chem Int Ed Engl. 2002. PMID: 12203440 No abstract available.

7

Cooperative binding of p53 to DNA: regulation by protein-protein interactions through a double salt bridge.

Dehner A, Klein C, Hansen S, Müller L, Buchner J, Schwaiger M, Kessler H. Dehner A, et al. Among authors: kessler h. Angew Chem Int Ed Engl. 2005 Aug 19;44(33):5247-51. doi: 10.1002/anie.200501887. Angew Chem Int Ed Engl. 2005. PMID: 16035029 No abstract available.

8

Probing integrin selectivity: rational design of highly active and selective ligands for the alpha5beta1 and alphavbeta3 integrin receptor.

Heckmann D, Meyer A, Marinelli L, Zahn G, Stragies R, Kessler H. Heckmann D, et al. Among authors: kessler h. Angew Chem Int Ed Engl. 2007;46(19):3571-4. doi: 10.1002/anie.200700008. Angew Chem Int Ed Engl. 2007. PMID: 17394271 No abstract available.

9

Multiple N-methylation by a designed approach enhances receptor selectivity.

Chatterjee J, Ovadia O, Zahn G, Marinelli L, Hoffman A, Gilon C, Kessler H. Chatterjee J, et al. Among authors: kessler h. J Med Chem. 2007 Nov 29;50(24):5878-81. doi: 10.1021/jm701044r. Epub 2007 Nov 1. J Med Chem. 2007. PMID: 17973471

10

Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues.

Biron E, Chatterjee J, Ovadia O, Langenegger D, Brueggen J, Hoyer D, Schmid HA, Jelinek R, Gilon C, Hoffman A, Kessler H. Biron E, et al. Among authors: kessler h. Angew Chem Int Ed Engl. 2008;47(14):2595-9. doi: 10.1002/anie.200705797. Angew Chem Int Ed Engl. 2008. PMID: 18297660 No abstract available.

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