Reduced myocyte complex N-glycosylation causes dilated cardiomyopathy.
Ednie AR, Deng W, Yip KP, Bennett ES.
Ednie AR, et al. Among authors: deng w.
FASEB J. 2019 Jan;33(1):1248-1261. doi: 10.1096/fj.201801057R. Epub 2018 Aug 23.
FASEB J. 2019.
PMID: 30138037
Free PMC article.
Thus, the Mgat1KO provides a model for investigating the relationship between systemic reductions in glycosylation and cardiac disease, showing that clinically relevant changes in cardiomyocyte hybrid/complex N-glycosylation are sufficient to cause DCM and early death.-Ednie, A. …
Thus, the Mgat1KO provides a model for investigating the relationship between systemic reductions in glycosylation and cardiac disease, show …