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Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor.
ACS Med Chem Lett. 2018 Jul 26;9(8):815-820. doi: 10.1021/acsmedchemlett.8b00214. eCollection 2018 Aug 9.
ACS Med Chem Lett. 2018.
PMID: 30128073
Free PMC article.
A conformational constraint improves a beta-secretase inhibitor but for an unexpected reason.
Hills ID, Holloway MK, de León P, Nomland A, Zhu H, Rajapakse H, Allison TJ, Munshi SK, Colussi D, Pietrak BL, Toolan D, Haugabook SJ, Graham SL, Stachel SJ.
Hills ID, et al.
Bioorg Med Chem Lett. 2009 Sep 1;19(17):4993-5. doi: 10.1016/j.bmcl.2009.07.071. Epub 2009 Jul 17.
Bioorg Med Chem Lett. 2009.
PMID: 19640712
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(E)-Alkenes as replacements of amide bonds: development of novel and potent acyclic CGRP receptor antagonists.
Kim JJ, Wood MR, Stachel SJ, de Leon P, Nomland A, Stump CA, McWherter MA, Schirripa KM, Moore EL, Salvatore CA, Selnick HG.
Kim JJ, et al.
Bioorg Med Chem Lett. 2014 Jan 1;24(1):258-61. doi: 10.1016/j.bmcl.2013.11.027. Epub 2013 Nov 20.
Bioorg Med Chem Lett. 2014.
PMID: 24332093
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Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy.
Skudlarek JW, Cooke AJ, Mitchell HJ, Babaoglu K, Shaw AW, Tong L, Nomland AB, Labroli M, Sha D, Mulhearn JJ, Wu C, Li SW, Beshore DC, Hughes JME, Jouffroy M, Wang H, Balibar CJ, Painter RE, Shen P, Lange HS, Ishchenko A, Chen YT, Klein DJ, Tracy RW, Miller RR, Cabalu TD, Wu Z, Leithead A, Scapin G, Hruza AW, Dzhekieva L, Bukhtiyarova M, Homsher MF, Xu M, Bahnck-Teets C, McKenney D, Buevich AV, Liu J, Zhang LK, Meng T, Kelly T, DiNunzio E, Soisson S, Cheng RKY, Hennig M, Raheem I, Walker SS.
Skudlarek JW, et al. Among authors: nomland ab.
J Med Chem. 2024 Sep 12;67(17):15620-15675. doi: 10.1021/acs.jmedchem.4c01277. Epub 2024 Aug 22.
J Med Chem. 2024.
PMID: 39172133
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