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Metastatic cells are preferentially vulnerable to lysosomal inhibition.
Morgan MJ, Fitzwalter BE, Owens CR, Powers RK, Sottnik JL, Gamez G, Costello JC, Theodorescu D, Thorburn A. Morgan MJ, et al. Among authors: costello jc. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8479-E8488. doi: 10.1073/pnas.1706526115. Epub 2018 Aug 20. Proc Natl Acad Sci U S A. 2018. PMID: 30127018 Free PMC article.
A community effort to assess and improve drug sensitivity prediction algorithms.
Costello JC, Heiser LM, Georgii E, Gönen M, Menden MP, Wang NJ, Bansal M, Ammad-ud-din M, Hintsanen P, Khan SA, Mpindi JP, Kallioniemi O, Honkela A, Aittokallio T, Wennerberg K; NCI DREAM Community; Collins JJ, Gallahan D, Singer D, Saez-Rodriguez J, Kaski S, Gray JW, Stolovitzky G. Costello JC, et al. Nat Biotechnol. 2014 Dec;32(12):1202-12. doi: 10.1038/nbt.2877. Epub 2014 Jun 1. Nat Biotechnol. 2014. PMID: 24880487 Free PMC article.
Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer.
Nickerson ML, Dancik GM, Im KM, Edwards MG, Turan S, Brown J, Ruiz-Rodriguez C, Owens C, Costello JC, Guo G, Tsang SX, Li Y, Zhou Q, Cai Z, Moore LE, Lucia MS, Dean M, Theodorescu D. Nickerson ML, et al. Among authors: costello jc. Clin Cancer Res. 2014 Sep 15;20(18):4935-48. doi: 10.1158/1078-0432.CCR-14-0330. Clin Cancer Res. 2014. PMID: 25225064 Free PMC article.
GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis.
Agarwal N, Dancik GM, Goodspeed A, Costello JC, Owens C, Duex JE, Theodorescu D. Agarwal N, et al. Among authors: costello jc. Cancer Res. 2016 Sep 1;76(17):5175-85. doi: 10.1158/0008-5472.CAN-16-1099. Epub 2016 Jun 16. Cancer Res. 2016. PMID: 27312530 Free PMC article.
92 results