Visser SAG - Search Results

1

Clinical Evaluation of MK-2640: An Insulin Analog With Glucose-Responsive Properties.

Krug AW, Visser SAG, Tsai K, Kandala B, Fancourt C, Thornton B, Morrow L, Kaarsholm NC, Bernstein HS, Stoch SA, Crutchlow M, Kelley DE, Iwamoto M. Krug AW, et al. Among authors: visser sag. Clin Pharmacol Ther. 2019 Feb;105(2):417-425. doi: 10.1002/cpt.1215. Epub 2018 Sep 30. Clin Pharmacol Ther. 2019. PMID: 30125349 Clinical Trial.

2

A Model-Informed Drug Discovery and Development Strategy for the Novel Glucose-Responsive Insulin MK-2640 Enabled Rapid Decision Making.

Visser SAG, Kandala B, Fancourt C, Krug AW, Cho CR. Visser SAG, et al. Clin Pharmacol Ther. 2020 Jun;107(6):1296-1311. doi: 10.1002/cpt.1729. Epub 2020 Feb 3. Clin Pharmacol Ther. 2020. PMID: 31889297 Free PMC article.

3

Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid.

van Hasselt JG, Rizk ML, Lala M, Chavez-Eng C, Visser SA, Kerbusch T, Danhof M, Rao G, van der Graaf PH. van Hasselt JG, et al. Br J Clin Pharmacol. 2016 Jun;81(6):1113-23. doi: 10.1111/bcp.12901. Epub 2016 Apr 1. Br J Clin Pharmacol. 2016. PMID: 26852277 Free PMC article. Clinical Trial.

4

The variability in beta-cell function in placebo-treated subjects with type 2 diabetes: application of the weight-HbA1c-insulin-glucose (WHIG) model.

Duong JK, de Winter W, Choy S, Plock N, Naik H, Krauwinkel W, Visser SA, Verhamme KM, Sturkenboom MC, Stricker BH, Danhof M. Duong JK, et al. Br J Clin Pharmacol. 2017 Mar;83(3):487-497. doi: 10.1111/bcp.13144. Epub 2016 Nov 17. Br J Clin Pharmacol. 2017. PMID: 27679422 Free PMC article.

5

Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use.

Nayak S, Sander O, Al-Huniti N, de Alwis D, Chain A, Chenel M, Sunkaraneni S, Agrawal S, Gupta N, Visser SAG. Nayak S, et al. Among authors: visser sag. Clin Pharmacol Ther. 2018 Mar;103(3):378-383. doi: 10.1002/cpt.978. Epub 2018 Jan 13. Clin Pharmacol Ther. 2018. PMID: 29330855 Free PMC article.

6

Toward Progress in Quantitative Translational Medicine: A Call to Action.

Venkatakrishnan K, Zheng S, Musante CJ, Jin JY, Riggs MM, Krishnaswami S, Visser SAG. Venkatakrishnan K, et al. Among authors: visser sag. Clin Pharmacol Ther. 2020 Jan;107(1):85-88. doi: 10.1002/cpt.1687. Epub 2019 Nov 21. Clin Pharmacol Ther. 2020. PMID: 31750932

7

Dose-dependent EEG effects of zolpidem provide evidence for GABA(A) receptor subtype selectivity in vivo.

Visser SA, Wolters FL, van der Graaf PH, Peletier LA, Danhof M. Visser SA, et al. J Pharmacol Exp Ther. 2003 Mar;304(3):1251-7. doi: 10.1124/jpet.102.044859. J Pharmacol Exp Ther. 2003. PMID: 12604703

8

A PK-PD model-based assessment of sugammadex effects on coagulation parameters.

Bosch R, van Lierop MJ, de Kam PJ, Kruithof AC, Burggraaf J, de Greef R, Visser SA, Johnson-Levonas AO, Kleijn HJ. Bosch R, et al. Eur J Pharm Sci. 2016 Mar 10;84:9-17. doi: 10.1016/j.ejps.2015.12.028. Epub 2015 Dec 30. Eur J Pharm Sci. 2016. PMID: 26747019 Clinical Trial.

9

Model-based evaluation of drug-induced QTc prolongation for compounds in early development.

Dubois VF, Yu H, Danhof M, Della Pasqua O; Cardiovascular Safety Project Team and TI Pharma PKPD Platform. Dubois VF, et al. Br J Clin Pharmacol. 2015 Jan;79(1):148-61. doi: 10.1111/bcp.12482. Br J Clin Pharmacol. 2015. PMID: 25099645 Free PMC article. Clinical Trial.

10

Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis.

Gotta V, Cools F, van Ammel K, Gallacher DJ, Visser SA, Sannajust F, Morissette P, Danhof M, van der Graaf PH. Gotta V, et al. Br J Pharmacol. 2015 Sep;172(17):4364-79. doi: 10.1111/bph.13218. Epub 2015 Jul 21. Br J Pharmacol. 2015. PMID: 26076100 Free PMC article.

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