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Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.
D'Souza AM, Jiang Y, Cast A, Valanejad L, Wright M, Lewis K, Kumbaji M, Shah S, Smithrud D, Karns R, Shin S, Timchenko N. D'Souza AM, et al. Among authors: timchenko n. Cell Mol Gastroenterol Hepatol. 2018 May 24;6(3):239-255. doi: 10.1016/j.jcmgh.2018.05.007. eCollection 2018. Cell Mol Gastroenterol Hepatol. 2018. PMID: 30109252 Free PMC article.
FXR-Gankyrin axis is involved in development of pediatric liver cancer.
Valanejad L, Lewis K, Wright M, Jiang Y, D'Souza A, Karns R, Sheridan R, Gupta A, Bove K, Witte D, Geller J, Tiao G, Nelson DL, Timchenko L, Timchenko N. Valanejad L, et al. Among authors: timchenko n, timchenko l. Carcinogenesis. 2017 Jul 1;38(7):738-747. doi: 10.1093/carcin/bgx050. Carcinogenesis. 2017. PMID: 28535186 Free PMC article.
HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer.
Rivas M, Johnston ME 2nd, Gulati R, Kumbaji M, Margues Aguiar TF, Timchenko L, Krepischi A, Shin S, Bondoc A, Tiao G, Geller J, Timchenko N. Rivas M, et al. Among authors: timchenko n, timchenko l. Cell Mol Gastroenterol Hepatol. 2021;12(5):1669-1682. doi: 10.1016/j.jcmgh.2021.06.026. Epub 2021 Jul 8. Cell Mol Gastroenterol Hepatol. 2021. PMID: 34245919 Free PMC article.
Akt-FoxO1 axis controls liver regeneration.
Valanejad L, Timchenko N. Valanejad L, et al. Among authors: timchenko n. Hepatology. 2016 May;63(5):1424-6. doi: 10.1002/hep.28440. Epub 2016 Mar 9. Hepatology. 2016. PMID: 27100144 No abstract available.
Small Molecule Cjoc42 Improves Chemo-Sensitivity and Increases Levels of Tumor Suppressor Proteins in Hepatoblastoma Cells and in Mice by Inhibiting Oncogene Gankyrin.
D'Souza AM, Cast A, Kumbaji M, Rivas M, Gulati R, Johnston M, Smithrud D, Geller J, Timchenko N. D'Souza AM, et al. Among authors: timchenko n. Front Pharmacol. 2021 Mar 4;12:580722. doi: 10.3389/fphar.2021.580722. eCollection 2021. Front Pharmacol. 2021. PMID: 33746747 Free PMC article.
206 results