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Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position.
Cousin D, Hummersone MG, Bradshaw TD, Zhang J, Moody CJ, Foreiter MB, Summers HS, Lewis W, Wheelhouse RT, Stevens MFG. Cousin D, et al. Among authors: wheelhouse rt. Medchemcomm. 2018 Jan 19;9(3):545-553. doi: 10.1039/c7md00554g. eCollection 2018 Mar 1. Medchemcomm. 2018. PMID: 30108945 Free PMC article.
Antitumour imidazotetrazines: past, present… and future?
Stevens MFG, Wheelhouse RT. Stevens MFG, et al. Among authors: wheelhouse rt. RSC Chem Biol. 2023 Aug 29;4(10):736-741. doi: 10.1039/d3cb00076a. eCollection 2023 Oct 4. RSC Chem Biol. 2023. PMID: 37799580 Free PMC article. Review.
The medicinal chemistry of imidazotetrazine prodrugs.
Moody CL, Wheelhouse RT. Moody CL, et al. Among authors: wheelhouse rt. Pharmaceuticals (Basel). 2014 Jul 10;7(7):797-838. doi: 10.3390/ph7070797. Pharmaceuticals (Basel). 2014. PMID: 25014631 Free PMC article.
30 results