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Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position.
Cousin D, Hummersone MG, Bradshaw TD, Zhang J, Moody CJ, Foreiter MB, Summers HS, Lewis W, Wheelhouse RT, Stevens MFG. Cousin D, et al. Among authors: summers hs. Medchemcomm. 2018 Jan 19;9(3):545-553. doi: 10.1039/c7md00554g. eCollection 2018 Mar 1. Medchemcomm. 2018. PMID: 30108945 Free PMC article.
In search of effective therapies to overcome resistance to Temozolomide in brain tumours.
Bouzinab K, Summers H, Zhang J, Stevens MFG, Moody CJ, Turyanska L, Thomas NR, Gershkovich P, Ashford MB, Vitterso E, Storer LCD, Grundy R, Bradshaw TD. Bouzinab K, et al. Cancer Drug Resist. 2019 Dec 19;2(4):1018-1031. doi: 10.20517/cdr.2019.64. eCollection 2019. Cancer Drug Resist. 2019. PMID: 35582280 Free PMC article. Review.