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AVE0118, blocker of the transient outward current (I(to)) and ultrarapid delayed rectifier current (I(Kur)), fully restores atrial contractility after cardioversion of atrial fibrillation in the goat.
de Haan S, Greiser M, Harks E, Blaauw Y, van Hunnik A, Verheule S, Allessie M, Schotten U. de Haan S, et al. Among authors: van hunnik a. Circulation. 2006 Sep 19;114(12):1234-42. doi: 10.1161/CIRCULATIONAHA.106.630905. Epub 2006 Aug 28. Circulation. 2006. PMID: 16940189
Left ventricular septal and left ventricular apical pacing chronically maintain cardiac contractile coordination, pump function and efficiency.
Mills RW, Cornelussen RN, Mulligan LJ, Strik M, Rademakers LM, Skadsberg ND, van Hunnik A, Kuiper M, Lampert A, Delhaas T, Prinzen FW. Mills RW, et al. Among authors: van hunnik a. Circ Arrhythm Electrophysiol. 2009 Oct;2(5):571-9. doi: 10.1161/CIRCEP.109.882910. Epub 2009 Aug 25. Circ Arrhythm Electrophysiol. 2009. PMID: 19843926
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