Tochio N - Search Results

1

The trans isomer of Tau peptide is prone to aggregate, and the WW domain of Pin1 drastically decreases its aggregation.

Ikura T, Tochio N, Kawasaki R, Matsuzaki M, Narita A, Kikumoto M, Utsunomiya-Tate N, Tate SI, Ito N. Ikura T, et al. Among authors: tochio n. FEBS Lett. 2018 Sep;592(18):3082-3091. doi: 10.1002/1873-3468.13218. Epub 2018 Aug 13. FEBS Lett. 2018. PMID: 30079475 Free article.

2

Allosteric Breakage of the Hydrogen Bond within the Dual-Histidine Motif in the Active Site of Human Pin1 PPIase.

Wang J, Tochio N, Kawasaki R, Tamari Y, Xu N, Uewaki J, Utsunomiya-Tate N, Tate S. Wang J, et al. Among authors: tochio n. Biochemistry. 2015 Aug 25;54(33):5242-53. doi: 10.1021/acs.biochem.5b00606. Epub 2015 Aug 13. Biochemistry. 2015. PMID: 26226559

3

Dynamic Allostery Modulates Catalytic Activity by Modifying the Hydrogen Bonding Network in the Catalytic Site of Human Pin1.

Wang J, Kawasaki R, Uewaki JI, Rashid AUR, Tochio N, Tate SI. Wang J, et al. Among authors: tochio n. Molecules. 2017 Jun 15;22(6):992. doi: 10.3390/molecules22060992. Molecules. 2017. PMID: 28617332 Free PMC article.

4

The C113D mutation in human Pin1 causes allosteric structural changes in the phosphate binding pocket of the PPIase domain through the tug of war in the dual-histidine motif.

Xu N, Tochio N, Wang J, Tamari Y, Uewaki J, Utsunomiya-Tate N, Igarashi K, Shiraki T, Kobayashi N, Tate S. Xu N, et al. Among authors: tochio n. Biochemistry. 2014 Sep 2;53(34):5568-78. doi: 10.1021/bi5007817. Epub 2014 Aug 20. Biochemistry. 2014. PMID: 25100325

5

Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication.

Umehara K, Hoshikawa M, Tochio N, Tate SI. Umehara K, et al. Among authors: tochio n. Molecules. 2018 Feb 27;23(3):528. doi: 10.3390/molecules23030528. Molecules. 2018. PMID: 29495458 Free PMC article.

6

Effect of site-specific amino acid D-isomerization on β-sheet transition and fibril formation profiles of Tau microtubule-binding repeat peptides.

Tochio N, Murata T, Utsunomiya-Tate N. Tochio N, et al. Biochem Biophys Res Commun. 2019 Jan 1;508(1):184-190. doi: 10.1016/j.bbrc.2018.11.043. Epub 2018 Nov 22. Biochem Biophys Res Commun. 2019. PMID: 30471859

7

Physicochemical characterization of the G51D mutation of α-synuclein that is responsible for its severe cytotoxicity.

Murata T, Tochio N, Utsunomiya-Tate N. Murata T, et al. Among authors: tochio n. Neurosci Lett. 2021 Aug 24;760:136077. doi: 10.1016/j.neulet.2021.136077. Epub 2021 Jun 20. Neurosci Lett. 2021. PMID: 34161822

8

Ultrasensitive Change in Nucleosome Binding by Multiple Phosphorylations to the Intrinsically Disordered Region of the Histone Chaperone FACT.

Aoki D, Awazu A, Fujii M, Uewaki JI, Hashimoto M, Tochio N, Umehara T, Tate SI. Aoki D, et al. Among authors: tochio n. J Mol Biol. 2020 Jul 24;432(16):4637-4657. doi: 10.1016/j.jmb.2020.06.011. Epub 2020 Jun 15. J Mol Biol. 2020. PMID: 32553729

9

Non-RVD mutations that enhance the dynamics of the TAL repeat array along the superhelical axis improve TALEN genome editing efficacy.

Tochio N, Umehara K, Uewaki JI, Flechsig H, Kondo M, Dewa T, Sakuma T, Yamamoto T, Saitoh T, Togashi Y, Tate SI. Tochio N, et al. Sci Rep. 2016 Nov 24;6:37887. doi: 10.1038/srep37887. Sci Rep. 2016. PMID: 27883072 Free PMC article.

10

Remaining structures at the N- and C-terminal regions of alpha-synuclein accurately elucidated by amide-proton exchange NMR with fitting.

Okazaki H, Ohori Y, Komoto M, Lee YH, Goto Y, Tochio N, Nishimura C. Okazaki H, et al. Among authors: tochio n. FEBS Lett. 2013 Nov 15;587(22):3709-14. doi: 10.1016/j.febslet.2013.09.039. Epub 2013 Oct 7. FEBS Lett. 2013. PMID: 24113654 Free article.

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