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Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Nature. 2018 Aug;560(7717):253-257. doi: 10.1038/s41586-018-0387-5. Epub 2018 Aug 1.
Nature. 2018.
PMID: 30069049
MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway.
Sheikh BN, Phipson B, El-Saafin F, Vanyai HK, Downer NL, Bird MJ, Kueh AJ, May RE, Smyth GK, Voss AK, Thomas T.
Sheikh BN, et al. Among authors: downer nl.
Oncogene. 2015 Nov 19;34(47):5807-20. doi: 10.1038/onc.2015.33. Epub 2015 Mar 16.
Oncogene. 2015.
PMID: 25772242
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Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
Priebbenow DL, Leaver DJ, Nguyen N, Cleary B, Lagiakos HR, Sanchez J, Xue L, Huang F, Sun Y, Mujumdar P, Mudududdla R, Varghese S, Teguh S, Charman SA, White KL, Shackleford DM, Katneni K, Cuellar M, Strasser JM, Dahlin JL, Walters MA, Street IP, Monahan BJ, Jarman KE, Jousset Sabroux H, Falk H, Chung MC, Hermans SJ, Downer NL, Parker MW, Voss AK, Thomas T, Baell JB.
Priebbenow DL, et al. Among authors: downer nl.
J Med Chem. 2020 May 14;63(9):4655-4684. doi: 10.1021/acs.jmedchem.9b02071. Epub 2020 Mar 19.
J Med Chem. 2020.
PMID: 32118427
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Excessive versus physiologically relevant levels of retinoic acid in embryonic stem cell differentiation.
Sheikh BN, Downer NL, Kueh AJ, Thomas T, Voss AK.
Sheikh BN, et al. Among authors: downer nl.
Stem Cells. 2014 Jun;32(6):1451-8. doi: 10.1002/stem.1604.
Stem Cells. 2014.
PMID: 25099890
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MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo.
Sheikh BN, Downer NL, Phipson B, Vanyai HK, Kueh AJ, McCarthy DJ, Smyth GK, Thomas T, Voss AK.
Sheikh BN, et al. Among authors: downer nl.
Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5437-42. doi: 10.1073/pnas.1422872112. Epub 2015 Apr 14.
Proc Natl Acad Sci U S A. 2015.
PMID: 25922517
Free PMC article.
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Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription.
El-Saafin F, Curry C, Ye T, Garnier JM, Kolb-Cheynel I, Stierle M, Downer NL, Dixon MP, Negroni L, Berger I, Thomas T, Voss AK, Dobyns W, Devys D, Tora L.
El-Saafin F, et al. Among authors: downer nl.
Hum Mol Genet. 2018 Jun 15;27(12):2171-2186. doi: 10.1093/hmg/ddy126.
Hum Mol Genet. 2018.
PMID: 29648665
Free PMC article.
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Internode length is reduced during myelination and remyelination by neurofilament medium phosphorylation in motor axons.
Villalón E, Barry DM, Byers N, Frizzi K, Jones MR, Landayan DS, Dale JM, Downer NL, Calcutt NA, Garcia ML.
Villalón E, et al. Among authors: downer nl.
Exp Neurol. 2018 Aug;306:158-168. doi: 10.1016/j.expneurol.2018.05.009. Epub 2018 May 14.
Exp Neurol. 2018.
PMID: 29772247
Free PMC article.
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Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice.
Smith CM, Hosken IT, Downer NL, Chua BE, Hossain MA, Wade JD, Gundlach AL.
Smith CM, et al. Among authors: downer nl.
Ital J Anat Embryol. 2013;118(1 Suppl):52-5.
Ital J Anat Embryol. 2013.
PMID: 24640572
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