Luk LYP - Search Results

1

Reactivity and Selectivity of Iminium Organocatalysis Improved by a Protein Host.

Nödling AR, Świderek K, Castillo R, Hall JW, Angelastro A, Morrill LC, Jin Y, Tsai YH, Moliner V, Luk LYP. Nödling AR, et al. Among authors: luk lyp. Angew Chem Int Ed Engl. 2018 Sep 17;57(38):12478-12482. doi: 10.1002/anie.201806850. Epub 2018 Aug 23. Angew Chem Int Ed Engl. 2018. PMID: 30027571 Free PMC article.

2

Unraveling the role of protein dynamics in dihydrofolate reductase catalysis.

Luk LY, Javier Ruiz-Pernía J, Dawson WM, Roca M, Loveridge EJ, Glowacki DR, Harvey JN, Mulholland AJ, Tuñón I, Moliner V, Allemann RK. Luk LY, et al. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16344-9. doi: 10.1073/pnas.1312437110. Epub 2013 Sep 24. Proc Natl Acad Sci U S A. 2013. PMID: 24065822 Free PMC article.

3

Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase.

Ruiz-Pernia JJ, Luk LY, García-Meseguer R, Martí S, Loveridge EJ, Tuñón I, Moliner V, Allemann RK. Ruiz-Pernia JJ, et al. J Am Chem Soc. 2013 Dec 11;135(49):18689-96. doi: 10.1021/ja410519h. Epub 2013 Nov 26. J Am Chem Soc. 2013. PMID: 24252106 Free PMC article.

4

Protein isotope effects in dihydrofolate reductase from Geobacillus stearothermophilus show entropic-enthalpic compensatory effects on the rate constant.

Luk LY, Ruiz-Pernía JJ, Dawson WM, Loveridge EJ, Tuñón I, Moliner V, Allemann RK. Luk LY, et al. J Am Chem Soc. 2014 Dec 10;136(49):17317-23. doi: 10.1021/ja5102536. Epub 2014 Nov 26. J Am Chem Soc. 2014. PMID: 25396728

5

Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase.

Luk LY, Ruiz-Pernía JJ, Adesina AS, Loveridge EJ, Tuñón I, Moliner V, Allemann RK. Luk LY, et al. Angew Chem Int Ed Engl. 2015 Jul 27;54(31):9016-20. doi: 10.1002/anie.201503968. Epub 2015 Jun 16. Angew Chem Int Ed Engl. 2015. PMID: 26079622 Free PMC article.

6

Reduction of Folate by Dihydrofolate Reductase from Thermotoga maritima.

Loveridge EJ, Hroch L, Hughes RL, Williams T, Davies RL, Angelastro A, Luk LY, Maglia G, Allemann RK. Loveridge EJ, et al. Biochemistry. 2017 Apr 4;56(13):1879-1886. doi: 10.1021/acs.biochem.6b01268. Epub 2017 Mar 24. Biochemistry. 2017. PMID: 28319664 Free article.

7

Site-specific His/Asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance.

Lai SJ, Tu IF, Wu WL, Yang JT, Luk LYP, Lai MC, Tsai YH, Wu SH. Lai SJ, et al. Among authors: luk lyp. BMC Microbiol. 2017 May 25;17(1):123. doi: 10.1186/s12866-017-1034-2. BMC Microbiol. 2017. PMID: 28545444 Free PMC article.

8

Chemoenzymatic Assembly of Isotopically Labeled Folates.

Angelastro A, Dawson WM, Luk LYP, Loveridge EJ, Allemann RK. Angelastro A, et al. Among authors: luk lyp. J Am Chem Soc. 2017 Sep 20;139(37):13047-13054. doi: 10.1021/jacs.7b06358. Epub 2017 Sep 6. J Am Chem Soc. 2017. PMID: 28820585

9

Reaction Mechanism of Organocatalytic Michael Addition of Nitromethane to Cinnamaldehyde: A Case Study on Catalyst Regeneration and Solvent Effects.

Świderek K, Nödling AR, Tsai YH, Luk LYP, Moliner V. Świderek K, et al. Among authors: luk lyp. J Phys Chem A. 2018 Jan 11;122(1):451-459. doi: 10.1021/acs.jpca.7b11803. Epub 2018 Jan 2. J Phys Chem A. 2018. PMID: 29256614 Free PMC article.

10

Isotope Substitution of Promiscuous Alcohol Dehydrogenase Reveals the Origin of Substrate Preference in the Transition State.

Behiry EM, Ruiz-Pernia JJ, Luk L, Tuñón I, Moliner V, Allemann RK. Behiry EM, et al. Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3128-3131. doi: 10.1002/anie.201712826. Epub 2018 Feb 19. Angew Chem Int Ed Engl. 2018. PMID: 29341402 Free PMC article.

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