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Mechanism-based corrector combination restores ΔF508-CFTR folding and function.
Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL. Okiyoneda T, et al. Among authors: lukacs gl. Nat Chem Biol. 2013 Jul;9(7):444-54. doi: 10.1038/nchembio.1253. Epub 2013 May 12. Nat Chem Biol. 2013. PMID: 23666117 Free PMC article.
Single-particle electron microscopy structure of UDP-glucose:glycoprotein glucosyltransferase suggests a selectivity mechanism for misfolded proteins.
Calles-Garcia D, Yang M, Soya N, Melero R, Ménade M, Ito Y, Vargas J, Lukacs GL, Kollman JM, Kozlov G, Gehring K. Calles-Garcia D, et al. Among authors: lukacs gl. J Biol Chem. 2017 Jul 7;292(27):11499-11507. doi: 10.1074/jbc.M117.789495. Epub 2017 May 10. J Biol Chem. 2017. PMID: 28490633 Free PMC article.
PINK1 autophosphorylation is required for ubiquitin recognition.
Rasool S, Soya N, Truong L, Croteau N, Lukacs GL, Trempe JF. Rasool S, et al. Among authors: lukacs gl. EMBO Rep. 2018 Apr;19(4):e44981. doi: 10.15252/embr.201744981. Epub 2018 Feb 23. EMBO Rep. 2018. PMID: 29475881 Free PMC article.
Mechanism of parkin activation by phosphorylation.
Sauvé V, Sung G, Soya N, Kozlov G, Blaimschein N, Miotto LS, Trempe JF, Lukacs GL, Gehring K. Sauvé V, et al. Among authors: lukacs gl. Nat Struct Mol Biol. 2018 Jul;25(7):623-630. doi: 10.1038/s41594-018-0088-7. Epub 2018 Jul 2. Nat Struct Mol Biol. 2018. PMID: 29967542
Identification of Allosteric Inhibitors against Active Caspase-6.
Tubeleviciute-Aydin A, Beautrait A, Lynham J, Sharma G, Gorelik A, Deny LJ, Soya N, Lukacs GL, Nagar B, Marinier A, LeBlanc AC. Tubeleviciute-Aydin A, et al. Among authors: lukacs gl. Sci Rep. 2019 Apr 2;9(1):5504. doi: 10.1038/s41598-019-41930-7. Sci Rep. 2019. PMID: 30940883 Free PMC article.
Nanomechanics combined with HDX reveals allosteric drug binding sites of CFTR NBD1.
Padányi R, Farkas B, Tordai H, Kiss B, Grubmüller H, Soya N, Lukács GL, Kellermayer M, Hegedűs T. Padányi R, et al. Among authors: lukacs gl. Comput Struct Biotechnol J. 2022 May 23;20:2587-2599. doi: 10.1016/j.csbj.2022.05.036. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35685375 Free PMC article.
171 results