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Page 1
Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.
Vandekeere S, Dubois C, Kalucka J, Sullivan MR, García-Caballero M, Goveia J, Chen R, Diehl FF, Bar-Lev L, Souffreau J, Pircher A, Kumar S, Vinckier S, Hirabayashi Y, Furuya S, Schoonjans L, Eelen G, Ghesquière B, Keshet E, Li X, Vander Heiden MG, Dewerchin M, Carmeliet P. Vandekeere S, et al. Among authors: vander heiden mg. Cell Metab. 2018 Oct 2;28(4):573-587.e13. doi: 10.1016/j.cmet.2018.06.009. Epub 2018 Jul 12. Cell Metab. 2018. PMID: 30017355 Free article.
Lack of Evidence for PKM2 Protein Kinase Activity.
Hosios AM, Fiske BP, Gui DY, Vander Heiden MG. Hosios AM, et al. Among authors: vander heiden mg. Mol Cell. 2015 Sep 3;59(5):850-7. doi: 10.1016/j.molcel.2015.07.013. Epub 2015 Aug 20. Mol Cell. 2015. PMID: 26300261 Free PMC article.
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM. Pacold ME, et al. Among authors: vander heiden mg. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. Nat Chem Biol. 2016. PMID: 27110680 Free PMC article.
The importance of serine metabolism in cancer.
Mattaini KR, Sullivan MR, Vander Heiden MG. Mattaini KR, et al. Among authors: vander heiden mg. J Cell Biol. 2016 Aug 1;214(3):249-57. doi: 10.1083/jcb.201604085. Epub 2016 Jul 25. J Cell Biol. 2016. PMID: 27458133 Free PMC article. Review.
When cancer needs what's non-essential.
Sullivan MR, Vander Heiden MG. Sullivan MR, et al. Among authors: vander heiden mg. Nat Cell Biol. 2017 May;19(5):418-420. doi: 10.1038/ncb3523. Epub 2017 Apr 19. Nat Cell Biol. 2017. PMID: 28422952
Aspartate is an endogenous metabolic limitation for tumour growth.
Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG. Sullivan LB, et al. Among authors: vander heiden mg. Nat Cell Biol. 2018 Jul;20(7):782-788. doi: 10.1038/s41556-018-0125-0. Epub 2018 Jun 25. Nat Cell Biol. 2018. PMID: 29941931 Free PMC article.
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.
Cox AG, Tsomides A, Yimlamai D, Hwang KL, Miesfeld J, Galli GG, Fowl BH, Fort M, Ma KY, Sullivan MR, Hosios AM, Snay E, Yuan M, Brown KK, Lien EC, Chhangawala S, Steinhauser ML, Asara JM, Houvras Y, Link B, Vander Heiden MG, Camargo FD, Goessling W. Cox AG, et al. Among authors: vander heiden mg. EMBO J. 2018 Nov 15;37(22):e100294. doi: 10.15252/embj.2018100294. Epub 2018 Oct 22. EMBO J. 2018. PMID: 30348863 Free PMC article.
252 results