Gupta A - Search Results

1

Facile target validation in an animal model with intracellularly expressed monobodies.

Gupta A, Xu J, Lee S, Tsai ST, Zhou B, Kurosawa K, Werner MS, Koide A, Ruthenburg AJ, Dou Y, Koide S. Gupta A, et al. Nat Chem Biol. 2018 Sep;14(9):895-900. doi: 10.1038/s41589-018-0099-z. Epub 2018 Jul 16. Nat Chem Biol. 2018. PMID: 30013062 Free PMC article.

2

Inhibition of RAS function through targeting an allosteric regulatory site.

Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP. Spencer-Smith R, et al. Among authors: gupta a. Nat Chem Biol. 2017 Jan;13(1):62-68. doi: 10.1038/nchembio.2231. Epub 2016 Nov 7. Nat Chem Biol. 2017. PMID: 27820802 Free PMC article.

3

Monobodies and other synthetic binding proteins for expanding protein science.

Sha F, Salzman G, Gupta A, Koide S. Sha F, et al. Among authors: gupta a. Protein Sci. 2017 May;26(5):910-924. doi: 10.1002/pro.3148. Epub 2017 Mar 24. Protein Sci. 2017. PMID: 28249355 Free PMC article. Review.

4

Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region.

Salzman GS, Zhang S, Gupta A, Koide A, Koide S, Araç D. Salzman GS, et al. Among authors: gupta a. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10095-10100. doi: 10.1073/pnas.1708810114. Epub 2017 Sep 5. Proc Natl Acad Sci U S A. 2017. PMID: 28874577 Free PMC article.

5

ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation.

Nady N, Gupta A, Ma Z, Swigut T, Koide A, Koide S, Wysocka J. Nady N, et al. Among authors: gupta a. Elife. 2015 Nov 2;4:e10150. doi: 10.7554/eLife.10150. Elife. 2015. PMID: 26523391 Free PMC article.

6

RNA induces conformational changes in the SF1/U2AF65 splicing factor complex.

Gupta A, Jenkins JL, Kielkopf CL. Gupta A, et al. J Mol Biol. 2011 Feb 4;405(5):1128-38. doi: 10.1016/j.jmb.2010.11.054. Epub 2010 Dec 10. J Mol Biol. 2011. PMID: 21146534 Free PMC article.

7

Structure of phosphorylated SF1 bound to U2AF⁶⁵ in an essential splicing factor complex.

Wang W, Maucuer A, Gupta A, Manceau V, Thickman KR, Bauer WJ, Kennedy SD, Wedekind JE, Green MR, Kielkopf CL. Wang W, et al. Among authors: gupta a. Structure. 2013 Feb 5;21(2):197-208. doi: 10.1016/j.str.2012.10.020. Epub 2012 Dec 27. Structure. 2013. PMID: 23273425 Free PMC article.

8

U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.

Jenkins JL, Agrawal AA, Gupta A, Green MR, Kielkopf CL. Jenkins JL, et al. Among authors: gupta a. Nucleic Acids Res. 2013 Apr 1;41(6):3859-73. doi: 10.1093/nar/gkt046. Epub 2013 Feb 1. Nucleic Acids Res. 2013. PMID: 23376934 Free PMC article.

9

Purification, crystallization and preliminary X-ray crystallographic analysis of a central domain of human splicing factor 1.

Gupta A, Kielkopf CL. Gupta A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt 4):486-90. doi: 10.1107/S1744309111004623. Epub 2011 Mar 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21505248 Free PMC article.

10

SF1 Phosphorylation Enhances Specific Binding to U2AF⁶⁵ and Reduces Binding to 3'-Splice-Site RNA.

Chatrikhi R, Wang W, Gupta A, Loerch S, Maucuer A, Kielkopf CL. Chatrikhi R, et al. Among authors: gupta a. Biophys J. 2016 Dec 20;111(12):2570-2586. doi: 10.1016/j.bpj.2016.11.007. Biophys J. 2016. PMID: 28002734 Free PMC article.

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