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AAVvector-mediated in vivo reprogramming into pluripotency.
Senís E, Mosteiro L, Wilkening S, Wiedtke E, Nowrouzi A, Afzal S, Fronza R, Landerer H, Abad M, Niopek D, Schmidt M, Serrano M, Grimm D. Senís E, et al. Among authors: serrano m. Nat Commun. 2018 Jul 9;9(1):2651. doi: 10.1038/s41467-018-05059-x. Nat Commun. 2018. PMID: 29985406 Free PMC article.
Reprogramming in vivo produces teratomas and iPS cells with totipotency features.
Abad M, Mosteiro L, Pantoja C, Cañamero M, Rayon T, Ors I, Graña O, Megías D, Domínguez O, Martínez D, Manzanares M, Ortega S, Serrano M. Abad M, et al. Among authors: serrano m. Nature. 2013 Oct 17;502(7471):340-5. doi: 10.1038/nature12586. Epub 2013 Sep 11. Nature. 2013. PMID: 24025773
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.
Mosteiro L, Pantoja C, Alcazar N, Marión RM, Chondronasiou D, Rovira M, Fernandez-Marcos PJ, Muñoz-Martin M, Blanco-Aparicio C, Pastor J, Gómez-López G, De Martino A, Blasco MA, Abad M, Serrano M. Mosteiro L, et al. Among authors: serrano m. Science. 2016 Nov 25;354(6315):aaf4445. doi: 10.1126/science.aaf4445. Science. 2016. PMID: 27884981
The Ink4/Arf locus is a barrier for iPS cell reprogramming.
Li H, Collado M, Villasante A, Strati K, Ortega S, Cañamero M, Blasco MA, Serrano M. Li H, et al. Among authors: serrano m. Nature. 2009 Aug 27;460(7259):1136-9. doi: 10.1038/nature08290. Epub 2009 Aug 9. Nature. 2009. PMID: 19668188 Free PMC article.
Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells.
Ruiz S, Lopez-Contreras AJ, Gabut M, Marion RM, Gutierrez-Martinez P, Bua S, Ramirez O, Olalde I, Rodrigo-Perez S, Li H, Marques-Bonet T, Serrano M, Blasco MA, Batada NN, Fernandez-Capetillo O. Ruiz S, et al. Among authors: serrano m. Nat Commun. 2015 Aug 21;6:8036. doi: 10.1038/ncomms9036. Nat Commun. 2015. PMID: 26292731 Free PMC article.
2,020 results