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Evaluation of Tolerability, Pharmacokinetics and Pharmacodynamics of Vicagrel, a Novel P2Y12 Antagonist, in Healthy Chinese Volunteers.
Li X, Liu C, Zhu X, Wei H, Zhang H, Chen H, Chen G, Yang D, Sun H, Shen Z, Zhang Y, Li W, Yang J, Liu Y, Lai X, Gong Y, Liu X, Li Y, Zhong D, Niu J, Liu B, Ding Y. Li X, et al. Among authors: gong y. Front Pharmacol. 2018 Jun 20;9:643. doi: 10.3389/fphar.2018.00643. eCollection 2018. Front Pharmacol. 2018. PMID: 29973877 Free PMC article.
Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma.
Liu C, Lu Y, Sun H, Yang J, Liu Y, Lai X, Gong Y, Liu X, Li Y, Zhang Y, Chen X, Zhong D. Liu C, et al. Among authors: gong y. J Pharm Biomed Anal. 2018 Feb 5;149:394-402. doi: 10.1016/j.jpba.2017.11.019. Epub 2017 Nov 6. J Pharm Biomed Anal. 2018. PMID: 29154109
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing.
Liu C, Zhang Y, Chen W, Lu Y, Li W, Liu Y, Lai X, Gong Y, Liu X, Li Y, Chen X, Li X, Sun H, Yang J, Zhong D. Liu C, et al. Among authors: gong y. Eur J Pharm Sci. 2019 Jan 15;127:151-160. doi: 10.1016/j.ejps.2018.10.011. Epub 2018 Oct 13. Eur J Pharm Sci. 2019. PMID: 30326264 Clinical Trial.
Impacts of CYP2C19 genetic polymorphisms on bioavailability and effect on platelet adhesion of vicagrel, a novel thienopyridine P2Y12 inhibitor.
Zhang Y, Zhu X, Zhan Y, Li X, Liu C, Zhu Y, Zhang H, Wei H, Xia Y, Sun H, Liu Y, Lai X, Gong Y, Liu X, Li Y, Ding Y, Zhong D. Zhang Y, et al. Among authors: gong y. Br J Clin Pharmacol. 2020 Sep;86(9):1860-1874. doi: 10.1111/bcp.14296. Epub 2020 Jun 17. Br J Clin Pharmacol. 2020. PMID: 32267573 Free PMC article. Clinical Trial.
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